Conformational change of X11L and its physiological functions

本研究旨在揭示AD的发病机制。类X11(X11L)蛋白被认为是AD发病的抑制因子。我们在本项目中发现，X11L的构象变化与Aβ的生成量有关，其构象变化受X11L蛋白的钙基末端的磷酸化调节。此外，我们还鉴定了一些X11L蛋白的候选蛋白。

The purpose of this research is to reveal the mechanism of AD pathogenesis. X11-like (X11L) protein has been identified as a suppressor of AD pathogenesis. We revealed in this project that the conformational change of X11L was correlated to the amount of Aβ generation and that its conformational change was regulated by the phosphorylation of calboxyl-terminal of X11L protein. Moreover, we identified a few candidate kinases of X11L protein.