Mechanisms underlying inhibition of human cytochrome P450 enzymesby major phytocannabinoids

研究了三种主要的植物大麻素THC、CBD和CBN对人细胞色素P450（CYP 450）活性的影响。THC、CBD和CBN对多种酶活性（CYP 1A 1、CYP 1A 2、CYP 1B 1、CYP 2A 6、CYP 2B 6、CYP 2C 9、CYP 2C 19、CYP 2D 6、CYP 2 J2、CYP 3A 4、CYP 3A 5、CYP 3A 7、CYP 4F 2、CYP 4F 3B、CYP 4F 12）均有不同程度的抑制作用。THC，CBD和CBN的抑制作用是可逆的（竞争性，非竞争性和混合型）和/或不可逆的，这取决于所检查的异构体。

Effects of three major phytocannabinoids, THC, CBD and CBN, onhuman cytochrome P450 (CYP) activities were investigated. THC, CBD and CBN inhibited manyCYP activities (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2J2,CYP3A4, CYP3A5, CYP3A7, CYP4F2, CYP4F3B, CYP4F12) to various extents. Inhibitions by THC,CBD and CBN were reversible (competitive, noncompetitive and mixed types) and/orirreversible depending on CYP isoforms examined.