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Properties of the L-type Ca^channel and its mutants

Properties of the L-type Ca^channel and its mutants
L型Ca^通道及其突变体的特性
批准号:
23790251
负责人:
MINOBE Etsuko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Properties of the L-type Ca^channel and its mutants were explored using inside-out patch-clamp technique. Activity of these channels was induced by calmodulin plus ATP. A protein phosphatase inhibitor okadaic acid could substitute for ATP in wild-type channels, but it not in the mutant channels. It was suggested that the effects of ATP and okadaic acid, although apparently similar, were mediated by different mechanisms.
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ATP directly binds to cardiac Ca^(Cav1.2) channels
ATP 直接结合心脏 Ca^(Cav1.2) 通道
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Rui Feng, Jianjun Xu, Etsuko Minobe, Asako Kameyama, Li-Ying Hao, Masaki Kameyama]
通讯作者: Masaki Kameyama
ATP directlybinds to cardiac Ca2+ (Cav1.2) channels.
ATP 直接与心脏 Ca2 (Cav1.2) 通道结合。
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Rui Feng, Jianjun Xu, Etsuko Minobe, Asako Kameyama, Li-Ying Hao, Masaki Kameyama]
通讯作者: Masaki Kameyama
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [蓑部悦子, Hadhimulya Asmara, Zahangir A. Saud, 亀山正樹]
通讯作者: 亀山正樹
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Masaki Kameyama, Etsuko Minobe, Hadhimulya Asmara, Zahangir A. Saud, Dong-yun Han, Jian-Jun Xu, Asako Kameyama and Li-ying Hao]
通讯作者: Asako Kameyama and Li-ying Hao
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    Regulation of L-type Ca^<2+> channel activity by calmodulin
    • 批准号:
      21790206
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2009
    • 负责人:
      MINOBE Etsuko
    • 依托单位:
    海外基金