NDRG2 deficient mice induces tumor formation and lifestyle related disease through the activation of AKT phosphorylation

我们报道了NDRG2 （N-myc下游调控基因2）是ATLL（成人t细胞白血病-淋巴瘤）肿瘤抑制基因的候选基因，它可以调节PI3K/AKT通路的信号转导。NDRG2缺陷小鼠出现各种类型的肿瘤，所有器官磷酸化AKT均升高。此外，我们指出，NDRG2缺陷小鼠与生活方式相关的疾病，如脑部疾病、心脏肥大和脂肪肝有关。这些发现提示ndrg2可能成为多种疾病的新的治疗靶点

We reported that NDRG2 (N-myc downstream-regulated gene 2) is a candidate for tumor suppressor gene in ATLL(adult T-cell leukemia-lymphoma), which can modulate signal transduction of PI3K/AKT pathway. NDRG2 deficient mice developed various type of tumor with increased phosphorylated AKT in all organs. Furthermore, we indicated that NDRG2 deficient mice associated with lifestyle related disease such as brain disease, cardiac hypertrophy and fatty liver. These finding suggest thatNDRG2 may become a new therapeutic target for many type of disease