Effect of Gasp overexpression in thymocytes

为了研究Gasp（Themis）在T细胞发育中的作用，我们以T细胞特异性方式制备了过表达Themis的转基因小鼠。在胸腺Themis过度表达增强了CD4 T细胞特异性的正选择，而CD8细胞的正选择被抑制。此外，Themis过度表达的外周T细胞中细胞因子的产生发生了改变。这些数据首次显示了Themis在T细胞受体依赖性信号传导中的作用。

In order to study the role of Gasp (Themis) in T cell development, we made transgenic mice overexpressing Themis in a T cell specific manner. In the thymus Themis overexpression augmented positive selection in a CD4 T cell specific manner, while positive selection of CD8 cells was inhibited. Furthermore, cytokine production was altered in Themis overexpressing peripheral T cells. These data show for the first time a role for Themis in T cell receptor-dependent signaling.