Development ofrapid cancer diagnosis by the novel electrospray ionization-mass spectrometry

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Probe electrospray ionization (PESI) is a biocompatible ambient ionization technique. We determined the conditions of measurements for lipids in human tissues. More than 3,000 spectra datasets were obtained from specimens of human renal cell carcinoma and hepatocellular carcinoma. These data were used as a training dataset, which serves as a reference for the dPLRM. We input randomly selected test datasets to the dPLRM to get probabilistic result of cancer diagnosis. We achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology.