Mechanisms of mobilization of human multipotent mesoangioblast.

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We previously identified circulating mesoangioblasts (cMABs), a subset of mesenchymal stem cells that co-express KDR and Nkx2.5, from the patients undergoing cardiac surgery with cardiopulmonary bypass. cMABs are capable of differentiating into endothelial cells, smooth muscle cells and cardiomyocytes. More recently, we demonstrated that hepatocyte growth factor (HGF) induces cMAB mobilization in animal model. We hypothesized that heparin induces cMAB mobilization in humans because it is well known that heparin can very rapidly up-regulate the serum levels of HGF. We found that heparin dose-dependently increased serum HGF levels and the number of cMABcolonies in patients with cardiac catheterization.