An investigation of a contribution of toll-like receptor signalinginhibitory molecules to connective tissue diseases

Toll样受体信号传导抑制分子对结缔组织疾病的影响的研究

• 批准号: 23791101
• 负责人: KAWASAKI Aya
• 金额: $ 2.75万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791101/
• 关键词: 全身性エリテマトーデス; 疾患感受性遺伝子; TLR; LILR; LAIR; PRDM1; 多型; SNP; IRF4

We examined whether genes encoding TLR7 and TLR9 signaling inhibitory molecules and related molecule, LILRA4, LAIR1 and IRF4 and PRDM1 are involved in the susceptibility to systemic lupus erythematosus (SLE). We detected the association of 4 SNPs in LILRA4-LAIR1. On the other hand, no evidence for association of IRF4 was observed. We also detected an association of PRDM1 with SLE with nephropathy.

我们检测编码TLR 7和TLR 9信号传导抑制分子及相关分子LILRA 4、LAIR 1和IRF 4和PRDM 1的基因是否参与系统性红斑狼疮（SLE）的易感性。我们检测了LILRA 4-LAIR 1中4个SNP的关联。另一方面，未观察到IRF 4相关的证据。我们还检测到PRDM 1与SLE肾病相关。

项目成果

Genetic background of antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population : association of STAT4 with myeloperoxidase antineutrophil cytoplasmic antibody-positive vasculitis

日本人群抗中性粒细胞胞浆抗体相关性血管炎的遗传背景：STAT4 与髓过氧化物酶抗中性粒细胞胞浆抗体阳性血管炎的关联

• 发表时间: 2012
• 作者: Kawasaki A;et al
• 通讯作者: et al