Metabolic and immunological impacts of growth hormone treatment in children with short stature born small for gestational age

生长激素治疗对出生小于胎龄身材矮小的儿童的代谢和免疫学影响

• 批准号: 23791184
• 负责人: ISHII Kanako
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791184/
• 关键词: SGA性低身長; 成長ホルモン; 脂質代謝; 子宮内発育遅延; 低身長

We studied on metabolic and immunological effects by growth hormone treatment (GH Tx) for one year in children with short stature born small for gestational age (SGA). We also evaluated the metabolic and immunological parameters for the patients before GH Tx compared with those for healthy controls. As a result, height SDS was improved 3 months after starting GH Tx in proportion to increase of serum IGF1 level. The HbA1c level before GH Tx in SGA children was higher than in controls, however, it did not worsen after GH Tx. The LDL-C level decreased by GH Tx, which indicated favorable effects of GH on lipid metabolism. Similarly, the many of serum apolipoprotein levels were considerably altered by GH Tx. Differences in counts of the white blood-cell, the neutrophil and the lymphocyte, and population of lymphocyte subsets were observed in between the patients before GH Tx and controls. GH Tx for the patients changed the levels of these hematological parameters toward those in controls.

我们研究了生长激素治疗（GH Tx）对小于胎龄儿（SGA）身材矮小儿童代谢和免疫的影响。我们还评估了GH Tx前患者的代谢和免疫学参数与健康对照组相比。因此，在开始GH Tx治疗后3个月，身高SDS与血清IGF 1水平的增加成比例地改善。SGA儿童GH Tx前HbA 1c水平高于对照组，但GH Tx后没有恶化。GH Tx降低LDL-C水平，表明GH对脂质代谢有良好的影响。同样，许多血清载脂蛋白水平显着改变GH Tx。 GH Tx前患者的白色细胞计数、中性粒细胞计数、淋巴细胞计数及淋巴细胞亚群计数均与对照组有显著性差异。患者的GH Tx改变了这些血液学参数的水平，使其接近对照组。

项目成果

GA性低身長に対するGH治療による代謝内分泌学的影響の検討

检查 GH 治疗对 GA 身材矮小的代谢和内分泌影响

• 发表时间: 2011
• 作者: 石井加奈子;井原健二;牧村美佳;野崎高史;大久保一宏;原寿郎
• 通讯作者: 原寿郎

SGA性低身長に対する成長ホルモン治療による代謝・免疫学的影響の検討

生长激素治疗对 SGA 身材矮小的代谢和免疫学影响的检查

• 发表时间: 2014
• 作者: 石井加奈子;井原健二;大久保一宏;松尾光通;戸田尚子;原寿郎
• 通讯作者: 原寿郎

The signal transducer and activator of transcription 5B gene polymorphism contributes to the cholesterol metabolism in Japanese children with growth hormone deficiency

• DOI: 10.1111/j.1365-2265.2011.03980.x
• 发表时间: 2011-05-01
• 期刊: CLINICAL ENDOCRINOLOGY
• 影响因子: 3.2
• 作者: Makimura, Mika;Ihara, Kenji;Hara, Toshiro
• 通讯作者: Hara, Toshiro

Coagulopathy in Patients With Late-Onset Ornithine Transcarbamylase Deficiency in Remission State: A Previously Unrecognized Complication

• DOI: 10.1542/peds.2012-0030
• 发表时间: 2013-01-01
• 期刊: PEDIATRICS
• 影响因子: 8
• 作者: Ihara, Kenji;Yoshino, Makoto;Hara, Toshiro
• 通讯作者: Hara, Toshiro

SGA性低身長に対するGH治療による血液・免疫学的影響の検討

GH 治疗对 SGA 身材矮小的血液学和免疫学影响的检查

• 发表时间: 2012
• 作者: 石井加奈子;井原健二;牧村美佳;野崎高史;大久保一宏;松尾光通;原寿郎
• 通讯作者: 原寿郎