Role of podoplanin in epidermal keratinocytes and psoriatic epidermis

平足蛋白在表皮角质形成细胞和银屑病表皮中的作用

• 批准号: 23791246
• 负责人: HONMA Masaru
• 金额: $ 1.25万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791246/
• 关键词: 表皮角化細胞; 有棘細胞癌; 皮膚癌; 幹細胞; 分化; 角化; 浸潤能; 遊走能; 乾癬; ポドプラニン; インテグリン; アデノウィルスベクター; 細胞遊走

Our results of epidermal keratinocytes show that podoplanin is associated with the regulatory mechanism of cell adhesion and self-renewal potency. This mechanism reflects both increased proliferating pool and increased transition into differentiation process of keratinocytes in prosiatic epidermis. In addition, we revealed the novel cell density-dependent PDPN-induction mechanism in squamous cell carcinoma cell-lines, which might play an important role in tumor progression process.

表皮角质形成细胞的研究结果表明，podoplanin与细胞粘附和自我更新能力的调节机制有关。这一机制反映了增生性表皮中角质形成细胞增殖池的增加和向分化过程的过渡的增加。此外，我们揭示了新的细胞密度依赖性PDPN诱导机制在鳞状细胞癌细胞系，这可能在肿瘤的进展过程中发挥重要作用。

项目成果

Rapidly progressive systemic sclerosis associated with breast carcinoma: report of a case with anti-RNA polymerase III antibody.

与乳腺癌相关的快速进展系统性硬化症：抗 RNA 聚合酶 III 抗体病例报告。

• DOI: 10.1111/j.1346-8138.2011.01345.x
• 发表时间: 2012
• 期刊: J Dermatol
• 影响因子: 3.1
• 作者: Honma M;Komatsu S;Igawa S;Murakami M;Iizuka H.
• 通讯作者: Iizuka H.

Intercellular contact augments EGF receptor expression to activate STAT3 which increases podoplanin expression in order to promote squamous cell carcinoma motility

细胞间接触增强 EGF 受体表达，激活 STAT3，从而增加足足蛋白表达，从而促进鳞状细胞癌运动

• 发表时间: 2013
• 期刊: Cell Signal
• 影响因子: 4.8
• 作者: Fujii M;Honma M;Takahashi H;et al
• 通讯作者: et al

Podoplanin alters 1-integrin-mediated cell adhesion and initiates terminal differentiation of human epidermal keratinocytes.

足平蛋白改变

• 发表时间: 2013
• 作者: Honma M;et al.
• 通讯作者: et al.

Japanese patients with psoriasis and atopic dermatitis show distinct personality profiles

• DOI: 10.1111/1346-8138.12087
• 发表时间: 2013-05
• 期刊: The Journal of Dermatology
• 作者: Hidetoshi Takahashi;H. Tsuji;M. Honma;Hikaru Shibaki;Satoshi Nakamura;Y. Hashimoto;Michinari Takahashi;Katsuya Koike;A. Takei;A. Ishida‐Yamamoto;H. Iizuka

Analytical prognostic survey of 105 Japanese cases of cutaneous T-cell lymphoma: clusterin expression as a novel prognostic factor

105 例日本皮肤 T 细胞淋巴瘤病例的分析预后调查：簇蛋白表达作为新的预后因素

• 发表时间: 2013
• 期刊: J Dermatol Sci
• 影响因子: 4.6
• 作者: Tobisawa S;Honma M;et al
• 通讯作者: et al