The role of the TWIST in Squamous cell carcinoma

TWIST 在鳞状细胞癌中的作用

• 批准号: 23791259
• 负责人: ISHII Takayuki
• 金额: $ 2.83万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791259/
• 关键词: 皮膚腫瘍学; 有棘細胞癌; TWIST; 上皮間葉移行

We examined the relationship between cutaneous Squamous cell carcinoma(cSCC) and TWIST, Snail, E-cadherin and Human papilloma virus(HPV). TWIST, Snail were over expressed in invasive cSCCs. On the other hand E-cadherin expressed low level in invasive cSCCs. We could not find the relationship between cSCCs and HPV. In cSCC insitu, these expression levels were same with invasive cases. Cell membrenes of keratinocytes were also stained with E-cadherin.

我们研究了皮肤鳞状细胞癌（cSCC）与TWIST、Snail、E-钙粘蛋白和人乳头瘤病毒（HPV）之间的关系。 TWIST、Snail 在侵袭性 cSCC 中过度表达。另一方面，E-钙粘蛋白在侵袭性 cSCC 中表达水平较低。我们无法找到cSCC和HPV之间的关系。在原位cSCC中，这些表达水平与侵袭性病例相同。角质形成细胞的细胞膜也用E-钙粘蛋白染色。