Challenge to reveal a novel role of central vasopressin and oxytocin neurons by optogenetic approach

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Neurohypophysial hormones are synthesized in the magnocellular neurosecretory cells (MNCs) localized in the hypothalamus, and they are secreted not only in the systemic circulation but also in the central nervous system. This study tried the optogenetic approaches to express the light-sensitive proteins in the MNCs to control neuronal activity by light exposure. The light-sensitive proteins were expressed in the transgenic rats. The functional evaluation should be performed by further study.