Possibility of transplantation of human skin-derived pluripotent stem cells into the bone marrow

人真皮成纤维细胞来源的MUSE细胞是一种多能干细胞(Kuroda等人，PNAS，2010)，通过尾静脉注入X射线照射的SICD小鼠。6个月后，在小鼠外周血中检测到人类白细胞和淋巴细胞标志物阳性的细胞。在骨髓中，建议将GFP标记的MUSE细胞分化为前红细胞标志物CD235a阳性细胞。从骨髓间充质组织中可获得多能的小鼠细胞，可用于骨髓移植。

Human dermal fibroblast-derived Muse cells, a type of pluripotent stem cells (Kuroda et al., PNAS, 2010), were infused into X-ray irradiated SICD mouse via tail vein. Six months after, cells positive for human leukocyte, lymphocytes markers were detected in theperipheral blood of the mice. In the bone marrow, GFP-labeled Muse cells were suggested to be differentiated into pre-erythroblast marker CD235a-positive cells. Pluripotent Muse cells that can be harvested from mesenchymal tissues are suggested to be applicable to bone marrow transplantation.