Identification of the genes related to longevity and cancer resistance in Naked mole-rats.

裸鼹鼠（Hg:Heterocephalus glaber）是一种极其长寿（30年）的老鼠大小的啮齿动物。除了长寿之外，裸鼹鼠对癌症有着非凡的抵抗力，因为在这些啮齿动物身上从未观察到过肿瘤。然而，造成这些现象的机制却完全不为人所知。为了研究这些机制，我们通过表达克隆分离了几个与长寿和抗癌有关的cdna。为此，我们从裸鼹鼠的肝脏和感染的MEF（小鼠胚胎成纤维细胞）或v-ras转化的NIH3T3细胞中生成了基于逆转录病毒的cDNA文库。在几种cDNA中，我们发现与中间丝相关的cDNA与裸鼹鼠的抗癌能力有关。

Naked mole-rats (Hg:Heterocephalus glaber) are extremely long-lived (30 years) mouse-sized rodents. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in these rodents. However, the mechanisms responsible for them were unknown at all.In order to examine these mechanisms, we isolated several cDNAs responsible for the longevity and cancer resistance by expression cloning. For these purposes, we generated the retrovirus-based cDNA libraries from the livers of the Naked mole-rats, and infected MEF (mouse embryo fibroblasts) or v-ras-transformed NIH3T3 cells. Of several cDNAs, we found cDNA related to intermediate filament was linked to cancer resistance in the Naked mole-rats.