Translational research of phama and food by greentea

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The present study aimed to evaluate the effect of catechin-rich green tea consumption on the pharmacokinetics of simvastatin lactone (SIM) and simvastatin acid (SVA). A single oral dose of SIM was administered to healthy Japanese male volunteers after drinking of green tea or water for 2 weeks. Blood samples were collected up to 24 h after the administration. Plasma concentrations of SIM and SVA were determined. Pharmacokinetic parameters were estimated by non-compartmental analysis. Chronic consumption of catechin-rich green tea increased the area under the plasma concentration-time curve (AUC) and maximum concentration (Cmax) of SIM. It also inhibited CYP enzymes in the liver. Thus, the chronic consumption of catechin-rich green tea may cause the clinically relevant interaction with simvastatin.