A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

含铁蛋白镭内辐射照射恶性间皮瘤发病机制的基础研究

• 批准号: 23659432
• 负责人: KIURA Katsuyuki
• 金额: $ 2.33万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659432/
• 关键词: 非閉塞性肺疾患癌; 悪性中皮腫; ラジウム; 生体内被曝; 鉄; 発癌; プリミティブマントル正規化微量原素パターン; ラット; 含鉄蛋白; 体内被曝; (1)含鉄蛋白質

Ten healthy male Slc: Wistar rats were repeatedly injected (i.p.) with a chelating agent and iron. Five of 10 rats showed a malignant peritoneal mesothelioma, but no rats showed it in the control and the chelating agent administration group. The tumor cells were positively stained by Calretinin and CEA. The results of immunostaining and the findings by electron microscope indicated epithelial mesothelioma. In addition, immunostaining with 8-hydroxy-2-deoxyguanosine is a DNA oxidative damage marker was positive. Thus, the conventional theoriy was confirmed. The final analysis of trace elements including radium is ongoing.

将10只健康雄性Slc：Wistar大鼠重复注射（i. p.）螯合剂和铁的混合物10只大鼠中有5只显示恶性腹膜间皮瘤，但在对照组和螯合剂给药组中没有大鼠显示恶性腹膜间皮瘤。肿瘤细胞Calretinin和CEA染色阳性。免疫组化及电镜检查结果提示为上皮性间皮瘤。此外，8-羟基-2-脱氧鸟苷免疫染色是DNA氧化损伤标志物，呈阳性。从而证实了传统的理论。目前正在对包括镭在内的微量元素进行最后分析。

项目成果

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer

• DOI: 10.1016/j.lungcan.2011.09.011
• 发表时间: 2012-04-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Ueno, Tsuyoshi;Tsukuda, Kazunori;Miyoshi, Shinichiro
• 通讯作者: Miyoshi, Shinichiro

Medical treatment of mesothelioma: anything new?

间皮瘤的医学治疗：有什么新的吗？

• DOI: 10.1007/s11912-011-0172-1
• 发表时间: 2011
• 期刊: Curr Oncol Rep
• 影响因子: 4.7
• 作者: Takigawa N;Kiura K;Kishimoto T
• 通讯作者: Kishimoto T

Is adenosine deaminase in pleural fluid a useful marker for differentiating tuberculosis from lung cancer or mesothelioma in Japan, a country with intermediate incidence of tuberculosis?

• DOI: 10.18926/amo/46851
• 发表时间: 2011-08
• 期刊: Acta medica Okayama
• 影响因子: 0.5
• 作者: Yoshiko Ogata;K. Aoe;A. Hiraki;K. Murakami;D. Kishino;K. Chikamori;T. Maeda;H. Ueoka;K. Kiura;M. Tanimoto