Role of CXCL14 as a sensor for behavior-stimulating substance

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In order to understand the role of CXCL14, I attempted to identify CXCL14 receptor molecules. As a result of GPCR knockdown experiments and cDNA rescue experiments using THP-1 cell line, I found that CXCL14 binds to CXCR4 with high affinity, and that another orphan GPCR (GPR14) was indispensable for the CXCL14-mediated signal transduction. CXCL14 cross-inhibited the chemotactic activity of CXCL12. GPR14- was abundantly expressed in mucosal tissues along with CXCL14. Therefore, GPR-14-interacting molecules could involved in the feeding behavior control by CXCL14.