Development of a novel disease severity marker for the inflammatory bowel diseases.

开发炎症性肠病的新型疾病严重程度标记。

• 批准号: 23659498
• 负责人: NAKATA Koh
• 金额: $ 2.33万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659498/
• 关键词: 炎症学; 内科; 免疫学; トランスレーショナルリサーチ; バイオテクノロジー; 蛋白症; 潰瘍性大腸炎; クローン病; 肺胞蛋白症; GM-CSF自己抗体; ELISA法

To develop a novel disease severity marker for Crohn's disease and ulceritive colitis, we invesitgated the concentration of IgG type and IgM type GM-CSF autoantibody concentrations in the sera from patients with Crohn's disease(n=44), ulcerative colitis(n=45), and normal subjects(n=43). The concentration of IgG antibody was under the detection limit in most subjects, but the concentration of IgM antibody was significantly higher in Crohn's disease than those in ulcerative disease and normal subjects. No significant correlation was found between the concentration and the disease severity.

为了开发克罗恩病和溃疡性结肠炎的新型疾病严重性标记，我们在克罗恩病患者的血清中IgG类型的浓度和IGM类型的GM-CSF自身抗体浓度（n = 44），溃疡性结肠炎（n = 45）和正常受试者（n = 43）。在大多数受试者中，IgG抗体的浓度在检测极限之下，但是在克罗恩病中，IgM抗体的浓度明显高于溃疡性疾病和正常受试者中的IgM抗体。浓度与疾病的严重程度之间未发现显着相关。

项目成果

Reduced GM-CSF autoantibody in improved lung of autoimune pulmonary alveolar proteinosis.

减少 GM-CSF 自身抗体，改善肺自身免疫性肺泡蛋白沉积症。

• 发表时间: 2012
• 期刊: Eur. Respir.J.
• 作者: Ohashi K;Sato A;Takada T;Inoue Y;Nakata K;Tazawa R.
• 通讯作者: Tazawa R.

IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis.

• DOI: 10.1152/ajplung.00378.2011
• 发表时间: 2012-05
• 期刊: American journal of physiology. Lung cellular and molecular physiology
• 作者: T. Nei;S. Urano;N. Motoi;J. Takizawa;C. Kaneko;H. Kanazawa;R. Tazawa;K. Nakagaki;K. Akagawa;K. Akasaka;T. Ichiwata;A. Azuma;K. Nakata

今日の治療指針 私はこう治療している 2012

今天的治疗指南 这就是我对待2012年的方式

• 发表时间: 2012
• 作者: 八木下尚子;荒谷聡子;佐藤知雄;藤井亮爾;山野嘉久;西岡久寿樹;中島利博;Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.Sumida,T.Mimori,Y.Tanaka,K.他andthe;中田 光
• 通讯作者: 中田 光

Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

• DOI: 10.1016/j.rinim.2011.11.001
• 发表时间: 2011-01-01
• 期刊: Results in immunology
• 作者: Saraya, Takeshi;Nakata, Koh;Goto, Hajime
• 通讯作者: Goto, Hajime

Bilateral Peripheral Infiltrates Refractory to Immunosuppressants were Diagnosed as Autoimmune Pulmonary Alveolar Proteinosis and Improved by Inhalation of Granulocyte/Macrophage-Colony Stimulating Factor

• DOI: 10.2169/internalmedicine.51.6093
• 发表时间: 2012-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Satoh, Hironori;Tazawa, Ryushi;Nukiwa, Toshihiro
• 通讯作者: Nukiwa, Toshihiro