Development of a novel disease severity marker for the inflammatory bowel diseases.

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To develop a novel disease severity marker for Crohn's disease and ulceritive colitis, we invesitgated the concentration of IgG type and IgM type GM-CSF autoantibody concentrations in the sera from patients with Crohn's disease(n=44), ulcerative colitis(n=45), and normal subjects(n=43). The concentration of IgG antibody was under the detection limit in most subjects, but the concentration of IgM antibody was significantly higher in Crohn's disease than those in ulcerative disease and normal subjects. No significant correlation was found between the concentration and the disease severity.