Development of a novel disease severity marker for the inflammatory bowel diseases.

开发炎症性肠病的新型疾病严重程度标记。

• 批准号: 23659498
• 负责人: NAKATA Koh
• 金额: $ 2.33万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659498/
• 关键词: 炎症学; 内科; 免疫学; トランスレーショナルリサーチ; バイオテクノロジー; 蛋白症; 潰瘍性大腸炎; クローン病; 肺胞蛋白症; GM-CSF自己抗体; ELISA法

To develop a novel disease severity marker for Crohn's disease and ulceritive colitis, we invesitgated the concentration of IgG type and IgM type GM-CSF autoantibody concentrations in the sera from patients with Crohn's disease(n=44), ulcerative colitis(n=45), and normal subjects(n=43). The concentration of IgG antibody was under the detection limit in most subjects, but the concentration of IgM antibody was significantly higher in Crohn's disease than those in ulcerative disease and normal subjects. No significant correlation was found between the concentration and the disease severity.

为了开发一种新的克罗恩病和溃疡性结肠炎的疾病严重程度标志物，我们调查了克罗恩病（n=44）、溃疡性结肠炎（n=45）和正常人（n=43）血清中IgG型和IgM型GM-CSF自身抗体的浓度。IgG抗体浓度在大多数受试者中低于检测限，但IgM抗体浓度在克罗恩病中显著高于溃疡性疾病和正常人。浓度与病情严重程度无显著相关性。

项目成果

Reduced GM-CSF autoantibody in improved lung of autoimune pulmonary alveolar proteinosis.

减少 GM-CSF 自身抗体，改善肺自身免疫性肺泡蛋白沉积症。

• 发表时间: 2012
• 期刊: Eur. Respir.J.
• 作者: Ohashi K;Sato A;Takada T;Inoue Y;Nakata K;Tazawa R.
• 通讯作者: Tazawa R.

Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis

• DOI: 10.1016/j.rmed.2011.10.019
• 发表时间: 2012-02-01
• 期刊: RESPIRATORY MEDICINE
• 影响因子: 4.3
• 作者: Ohashi, Kazumasa;Sato, Atsuyasu;Tazawa, Ryushi
• 通讯作者: Tazawa, Ryushi

IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis.

• DOI: 10.1152/ajplung.00378.2011
• 发表时间: 2012-05
• 期刊: American journal of physiology. Lung cellular and molecular physiology
• 作者: T. Nei;S. Urano;N. Motoi;J. Takizawa;C. Kaneko;H. Kanazawa;R. Tazawa;K. Nakagaki;K. Akagawa;K. Akasaka;T. Ichiwata;A. Azuma;K. Nakata

今日の治療指針 私はこう治療している 2012

今天的治疗指南 这就是我对待2012年的方式

• 发表时间: 2012
• 作者: 八木下尚子;荒谷聡子;佐藤知雄;藤井亮爾;山野嘉久;西岡久寿樹;中島利博;Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.Sumida,T.Mimori,Y.Tanaka,K.他andthe;中田 光
• 通讯作者: 中田 光

Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

• DOI: 10.1016/j.rinim.2011.11.001
• 发表时间: 2011-01-01
• 期刊: Results in immunology
• 作者: Saraya, Takeshi;Nakata, Koh;Goto, Hajime
• 通讯作者: Goto, Hajime