Noveltechnology for imuse cell induction.
Noveltechnology for imuse cell induction.
批准号:
23659648
负责人:
MORI Masaki
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
鉴于多系分化应激耐受(Muse)细胞存在于成人皮肤成纤维细胞和骨髓基质中,并且具有应激耐受性和内源性多能性,我们研究了miRNAs (iMuse细胞)诱导Muse样细胞的可能性。iMuse细胞安全高效,在再生医学中具有潜在的应用价值。而SSEA-3在正常细胞和癌细胞中的表达与代表性的干细胞标记物以及与间充质干细胞/Muse细胞标记物的表达有明确的关系。进一步的研究对于最终的临床设置是必要的。
英文摘要
Given that multilineage differentiating stress enduring (Muse) cells exist in adult skin fibroblasts and bone marrow stroma and possess stress tolerance and endogenous pluripotency, we studied the possible induction of Muse-like cells by miRNAs (iMuse cells). The iMuse cells have a potentially usefulness for the regenerative medicine as safety and efficiency. While expression of SSEA-3 showed specifically the relationship of representative stem markers as well as with mesenchymal stem cell/Muse cell markers in normal and cancer cells. Further study would be necessary for the final clinical setting.
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DOI:
--
发表时间:
2012
期刊:
Int J Oncol
影响因子:
5.2
作者:
[Nishikawa S.Dewi D., Ishii H., Konno M., Haraguchi N, Kano Y., Fukusumi T., Ohta K., Noguchi Y., Ozaki M., Sakai D., Satoh T., Doki Y., Mori M]
通讯作者:
Mori M
特集 Stem Cell, iPS研究;再生医療、癌診療への展開
特色:干细胞、iPS研究;再生医学和癌症治疗的发展
DOI:
--
发表时间:
2012
期刊:
肝胆膵
影响因子:
--
作者:
[Kenoki Ohuchida, Kazuhiro Mizumoto, Masao Tanaka., 森正樹]
通讯作者:
森正樹
パネルディスカッション1、大腸癌の悪性度診断と臨床応用
圆桌讨论1、结直肠癌的恶性肿瘤诊断及临床应用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[森正樹, 冨田尚裕]
通讯作者:
冨田尚裕
DOI:
10.3892/or.2012.2059
发表时间:
2012-12-01
期刊:
ONCOLOGY REPORTS
影响因子:
4.2
作者:
[Nishimura, Junichi, Handa, Rio, Mori, Masaki]
通讯作者:
Mori, Masaki
iPS Technology for Cancer Treatment
用于癌症治疗的 iPS 技术
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yusuke Sasaki, Katsuro Inoue, Mori M.]
通讯作者:
Mori M.
共 63 条
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Exploration of Galactic Cosmic-ray Origin with High Angular/Energy Resolution TeV Gamma-ray Observation
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Establishment of melecular-based diagnositics for esophageal cancer
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Simultaneous observation of TeV time-variable objects and gamma-ray burst afterglows with an optical telescope
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Simultaneous observation of time variable TeV gamma-ray objects in optical wavelength and monitoring of night sky
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Universe Seen From Very High Energy Eyes
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Clinical significance of molecular detection of carcinoma cells
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Molecular detection of cancer cells by RT-PCR
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Analysis of metastasis or morphology related genes in gastrolintestinal carcinoma
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Preoperative Hyperthermochemoradiotherapy for Patients with Rectal Cancer
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依托单位:
国内基金
海外基金
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