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Identification of Lung Cancer Stem Cell Markers

Identification of Lung Cancer Stem Cell Markers
肺癌干细胞标志物的鉴定
批准号:
23659664
负责人:
SUZUKI Motoshi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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英文摘要
By using clinical specimens, we performed IHC analysis for the putative cancer-initiating cell markers. Among the markers, we found CD166 may be the mostuseful one. To identify novel lung cancer-initiating cell markers, we analyzed an open database, screened genes that were highly expressed in CD166-positive cells, measured expression levels of such genes in the clinical specimens, and performed shRNA-induced knocking-down experiments. We identified that a gene could be a novel lung cancer-initiating cell marker, as well as a future target for the cancer treatment.
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Hybrid liposomes affect cellular lipid constituents and caveolae structures
混合脂质体影响细胞脂质成分和细胞膜穴结构
DOI: 10.1016/j.bmcl.2011.12.093
发表时间: 2012
期刊: Bioorg Med Chem Lett
影响因子: 2.7
作者: [吉川 豊, 藤本重行, 安井裕之, Cao K]
通讯作者: Cao K
A pivotal role of CerS6 on the ceramide metabolic pathways and tumor metastasis in lung cancer
CerS6对肺癌神经酰胺代谢途径和肿瘤转移的关键作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Motoshi Suzuki, Ke Cao, Kouji Tanaka, Seiichi Kato, Chinatsu Arima, Yasuyuki Hosono, Kiyoshi Yanagisawa, Keiko Tamiya-Koizumi, Takashi Murate, Mamoru Kyogashima and Takashi Takahashi]
通讯作者: Mamoru Kyogashima and Takashi Takahashi
DOI: 10.1016/j.bbrc.2012.10.036
发表时间: 2012-11-09
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [HosonoA, Yasuyuki, Usukura, Jiro, Takahashi, Takashi]
通讯作者: Takahashi, Takashi
DOI: 10.1038/emboj.2011.416
发表时间: 2012-01-18
期刊: EMBO JOURNAL
影响因子: 11.4
作者: [Hosono, Yasuyuki, Yamaguchi, Tomoya, Takahashi, Takashi]
通讯作者: Takahashi, Takashi
22
    Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells
    Identification of cancer initiating cell factors and an attempt of drug development
    • 批准号:
      26670625
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      SUZUKI Motoshi
    • 依托单位:
    Political Economic Analysis of Coalition Formation and Institutional Building in International Governance
    • 批准号:
      23330053
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.73万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Motoshi
    • 依托单位:
    Isolation of genomic instability genes that are associated with malignancy
    • 批准号:
      20590309
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
    • 负责人:
      SUZUKI Motoshi
    • 依托单位:
    海外基金