Liposome-encapsulated hemoglobin(LEH) accelerates bronchial healing after pneumonectomy in the rats without or with preoperative radiotherapy

脂质体包裹的血红蛋白（LEH）可加速大鼠肺切除术后支气管愈合（无论术前放疗与否）

• 批准号: 23659676
• 负责人: TAKEICHI Haruka
• 金额: $ 2.33万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659676/
• 关键词: リポソーム封入ヘモグロビン(LEH); 人工酸素運搬体; 気管支断端; 創傷治癒

Liposome-encapsulated hemoglobin(LEH) was reported to accelerate wound healing, LEH was tested in bronchial anastomotic healing after pneumonectomy without or with preoperative radiotherapy. Bronchial anastomotic healing was evaluated 2 days after surgery by determining the bursting pressure and infiltration of neutrophils, monocytes and macrophages. The bronchial bursting pressure was elevated in the rats receiving LEH eitherin untreated rats and in rats with preoperative radiation. Macrophage was significantly prominent in the LEH-treated rats regardless of the presence or absence of preoperative radiation. The results suggest that LEH may improve mechanical strength and morphological figures in bronchial anastomoses in rats regardless of presence or absence of preoperative radiotherapy to the chest.

据报道，脂质体包裹血红蛋白（莱赫）可加速伤口愈合，莱赫可用于肺切除术后支气管吻合口的愈合，无论术前放疗与否。术后2天，通过测定爆破压和中性粒细胞、单核细胞和巨噬细胞的浸润来评价支气管吻合口愈合。莱赫组和术前放疗组大鼠的支气管爆裂压均升高。巨噬细胞是显着突出的LEH治疗的大鼠，无论是否存在术前辐射。结果表明，莱赫可以改善大鼠支气管扩张的机械强度和形态学特征，无论术前是否有胸部放疗。

项目成果

Liposome-encapsulated hemoglobin ameliorates bronchial anastomotic healing after radiation and pneumonectomy in the rat

脂质体包裹的血红蛋白可改善大鼠放疗和肺切除术后的支气管吻合口愈合

• 发表时间: 2011
• 作者: Takeichi H;Kawaguchi AT
• 通讯作者: Kawaguchi AT

Liposome-encapsulated hemoglobin ameliorates bronchial anastomotic healing after radiation and pneumonectomy in the rats

脂质体包裹的血红蛋白可改善大鼠放疗和肺切除术后的支气管吻合口愈合

• 发表时间: 2011
• 作者: Yokota K;Sasaki H;Okuda K;Shimizu S;Shitara M;Hikosaka Y;Moriyama S;Yano M;Fujii Y;Haruka Takeichi
• 通讯作者: Haruka Takeichi