Neural network scale involved in genesis of hippocampal seizures

本研究旨在探讨癫痫发作发生的神经网络动力学机制。我们使用了光遗传诱导的海马区癫痫模型。记录大鼠海马区惊厥诱发过程中多点接触的局域场电位，并对其信息流进行统计分析。Granger因果关系分析揭示了沿海马轴纵轴的信息流在癫痫发作发生过程中的重要性。

This study was aimed to investigate neural network dynamics involved in the genesis of epileptic seizures. We used optogenetically induced model of hippocampal seizures. Multi-contact local field potentials were recorded during induction of hippocampal seizures and the information flow was analyzed statistically. Granger causality analysis revealed importance of information flow along longitudinal hippocampal axis during genesis of epileptic seizures.