Analysis of signal transduction pathways in brain pericytes in ischemic stroke
Analysis of signal transduction pathways in brain pericytes in ischemic stroke
批准号:
23659692
负责人:
SASAKI Tomio
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
近来有研究表明,脑周细胞在缺血性卒中中发挥着多种重要作用,但其具体机制尚不清楚。在我们的项目中,我们证明了碱性成纤维细胞生长因子(BFGFR)可以增强脑梗塞周围区周细胞中的PDGFFRβ信号,并介导细胞的生长、存活和神经营养因子的产生。
英文摘要
It has been suggested recently that brain pericytes play various important roles in ischemic stroke, but its detail mechnism remains elusive. In our project, we demonstrated that PDGFRβsignaling in brain pericytes in peri-infarct area was enhanced by basic fibroblast growth factor(bFGF) and mediated cell growth, survival and production of neurotrophic factors.
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くも膜下出血後のエンドセリンによる筋フィラメントのカルシウム感受性亢進の増強作用とその機序
内皮素增强蛛网膜下腔出血后肌丝钙敏感性及其机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[藤井 豊, 巽 英介, 白井幹康, 武輪能明, 妙中義之, Shimizu K, Sano S, Yudai Ohara, 木下 学, Nakagawa A, 吉川雄一郎]
通讯作者:
吉川雄一郎
Neuroprotective Role of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke
脑周细胞通过 PDGFRss-Akt 信号传导在缺血性中风中的神经保护作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T]
通讯作者:
Kitazono T
Neuroprotective Roles of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke
脑周细胞通过 PDGFRss-Akt 信号传导在缺血性中风中的神经保护作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T]
通讯作者:
Kitazono T
DOI:
10.2174/156720212799297100
发表时间:
2012-01
期刊:
Current neurovascular research
影响因子:
2.1
作者:
[K. Arimura;T. Ago;M. Kamouchi;Kuniyuki Nakamura;Koji Ishitsuka;J. Kuroda;H. Sugimori;H. Ooboshi;Tomio Sasaki;T. Kitazono]
通讯作者:
K. Arimura;T. Ago;M. Kamouchi;Kuniyuki Nakamura;Koji Ishitsuka;J. Kuroda;H. Sugimori;H. Ooboshi;Tomio Sasaki;T. Kitazono
脳虚血におけるPDGF-Bシグナルを介したペリサイトの神経保護作用
PDGF-B信号介导的周细胞对脑缺血的神经保护作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[有村公一, 吾郷哲朗, 杉森宏, 黒田淳 哉, 鴨打正浩, 佐々木富男, 北園孝成]
通讯作者:
北園孝成
共 6 条
Development of a novel therapeutic modality targeting G protein-coupled receptors for cerebral vasospasm after subarachnoid hemorrhage
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批准号:22249054
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$23.63万
-
财政年份:2010
-
负责人:SASAKI Tomio
-
依托单位:
Functional analysis of PAR-1 and search for novel G protein-coupled receptors in cerebral vasospasm
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批准号:18209045
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.45万
-
财政年份:2006
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负责人:SASAKI Tomio
-
依托单位:
The role of platelet-derived spasmogens and Rho/Rho-kinase pathway in the pathogenesis of cerebral vasospasm.
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批准号:14207053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.06万
-
财政年份:2002
-
负责人:SASAKI Tomio
-
依托单位:
Ca^<2+> sensitization and deficiency of myosin light chain dephosphorylation in the pathogenesis of cerebral vasospasm
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批准号:11307023
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$18.92万
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财政年份:1999
-
负责人:SASAKI Tomio
-
依托单位:
Pathogenesis of Cerebral Vasospasm ; Evaluation of Ca^<2+> sensitivity of contractile proteins.
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批准号:06454410
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.65万
-
财政年份:1994
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负责人:SASAKI Tomio
-
依托单位:
THE ROLE OF ENDOTHELIUM-DERIVED CONSTRICTING FACTOR(ENDOTHELIN) IN THE PATHOGENESIS OF CEREBRAL VASOSPASM
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批准号:01480349
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.14万
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财政年份:1989
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负责人:SASAKI Tomio
-
依托单位:
Pharmacological Studies of the Pathogenesis of Cerebral Vasospasm Following Subarachnoid Hemorrhage and its Treatment.
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批准号:62480304
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.52万
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财政年份:1987
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负责人:SASAKI Tomio
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依托单位:
海外基金