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Analysis of signal transduction pathways in brain pericytes in ischemic stroke

Analysis of signal transduction pathways in brain pericytes in ischemic stroke
缺血性脑卒中脑周细胞信号转导通路分析
批准号:
23659692
负责人:
SASAKI Tomio
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
翻译
近来有研究表明,脑周细胞在缺血性卒中中发挥着多种重要作用,但其具体机制尚不清楚。在我们的项目中,我们证明了碱性成纤维细胞生长因子(BFGFR)可以增强脑梗塞周围区周细胞中的PDGFFRβ信号,并介导细胞的生长、存活和神经营养因子的产生。
英文摘要
It has been suggested recently that brain pericytes play various important roles in ischemic stroke, but its detail mechnism remains elusive. In our project, we demonstrated that PDGFRβsignaling in brain pericytes in peri-infarct area was enhanced by basic fibroblast growth factor(bFGF) and mediated cell growth, survival and production of neurotrophic factors.
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会议论文
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [藤井 豊, 巽 英介, 白井幹康, 武輪能明, 妙中義之, Shimizu K, Sano S, Yudai Ohara, 木下 学, Nakagawa A, 吉川雄一郎]
通讯作者: 吉川雄一郎
Neuroprotective Role of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke
脑周细胞通过 PDGFRss-Akt 信号传导在缺血性中风中的神经保护作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T]
通讯作者: Kitazono T
Neuroprotective Roles of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke
脑周细胞通过 PDGFRss-Akt 信号传导在缺血性中风中的神经保护作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T]
通讯作者: Kitazono T
DOI: 10.2174/156720212799297100
发表时间: 2012-01
期刊: Current neurovascular research
影响因子: 2.1
作者: [K. Arimura;T. Ago;M. Kamouchi;Kuniyuki Nakamura;Koji Ishitsuka;J. Kuroda;H. Sugimori;H. Ooboshi;Tomio Sasaki;T. Kitazono]
通讯作者: K. Arimura;T. Ago;M. Kamouchi;Kuniyuki Nakamura;Koji Ishitsuka;J. Kuroda;H. Sugimori;H. Ooboshi;Tomio Sasaki;T. Kitazono
6
    Development of a novel therapeutic modality targeting G protein-coupled receptors for cerebral vasospasm after subarachnoid hemorrhage
    • 批准号:
      22249054
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $23.63万
    • 财政年份:
      2010
    • 负责人:
      SASAKI Tomio
    • 依托单位:
    Functional analysis of PAR-1 and search for novel G protein-coupled receptors in cerebral vasospasm
    • 批准号:
      18209045
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.45万
    • 财政年份:
      2006
    • 负责人:
      SASAKI Tomio
    • 依托单位:
    The role of platelet-derived spasmogens and Rho/Rho-kinase pathway in the pathogenesis of cerebral vasospasm.
    • 批准号:
      14207053
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $17.06万
    • 财政年份:
      2002
    • 负责人:
      SASAKI Tomio
    • 依托单位:
    Ca^<2+> sensitization and deficiency of myosin light chain dephosphorylation in the pathogenesis of cerebral vasospasm
    • 批准号:
      11307023
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $18.92万
    • 财政年份:
      1999
    • 负责人:
      SASAKI Tomio
    • 依托单位:
    海外基金