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The effects of food protein-derived metabolite, indoxyl sulfate, on progression of renal disease.

The effects of food protein-derived metabolite, indoxyl sulfate, on progression of renal disease.
食物蛋白衍生代谢物硫酸吲哚酚对肾脏疾病进展的影响。
批准号：
23700830
负责人：
SHIMIZU Hidehisa
金额：
$2.83万
依托单位：
Hokkaido University (2012)Nagoya University (2011)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700830/
关键词：
慢性腎不全尿毒症物質トリプトファン代謝物インドキシル硫酸細胞老化線維化炎症反応繊維化

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英文摘要
In patients with chronic kidney disease (CKD), serum indoxyl sulfate is elevated. Therefore, the present study examined what molecules are activated and expressed by indoxyl sulfate, and how indoxyl sulfate promotes CKD. Indoxyl sulfate activated ERK, p38, JNK, NF-?B, p53, Stat3, and CREB in proximal tubular cells. In addition, the expression of NOX4, TGF-?1, Smad3, ?-SMA, MCP-1, ICAM-1, and angiotensinogen was upregulated. Current study demonstrated that indoxyl sulfate induced macrophage infiltration, cellular senescence, and fibrosis through activation and expression of above-mentioned factors in process of CKD progression.
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Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells
DOI： 10.1016/j.lfs.2012.01.013
发表时间： 2012-04-09
期刊： LIFE SCIENCES
影响因子： 6.1
作者： [Shimizu, Hidehisa, Bolati, Dilinaer, Niwa, Toshimitsu]
通讯作者： Niwa, Toshimitsu
Accumulation and biological effects of metals in wild rats in mining areas of Zambia
DOI： 10.1007/s10661-012-2912-6
发表时间： 2013-06-01
期刊： ENVIRONMENTAL MONITORING AND ASSESSMENT
影响因子： 3
作者： [Nakayama, Shouta M. M., Ikenaka, Yoshinori, Ishizuka, Mayumi]
通讯作者： Ishizuka, Mayumi
Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts
山羊和大鼠胃肠道细胞色素 P450 3A mRNA 表达
DOI： --
发表时间： 2012
期刊： Jpn. J. Vet. Res.
影响因子： --
作者： [Dominic MUREITHI, Wageh Sobhy DARWISH, Yoshinori IKENAKA, Laetitia KANJA, Mayumi ISHIZUKA.]
通讯作者： Mayumi ISHIZUKA.
Stat3 is involved in indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence in proximal tubular cells.
Stat3 参与硫酸吲哚酚诱导的炎症和纤维化基因表达以及近端肾小管细胞的细胞衰老。
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Niwa, T., Nishijima, F., Shimizu, H.]
通讯作者： H.
Analysis of the disruption and recovery mechanism on gastrointestinal homeostasis by skatole produced by high animal protein intake
  • 批准号：
    18H03178
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $11.32万
  • 财政年份：
    2018
  • 负责人：
    SHIMIZU Hidehisa
  • 依托单位：
    Shimane University
Mechanism of chronic poisoning by exposure to low concentrations of microcystin and verification of mitigation methods in consideration of the intestinal environment
  • 批准号：
    18K19854
  • 项目类别：
    Grant-in-Aid for Challenging Research (Exploratory)
  • 资助金额：
    $4.08万
  • 财政年份：
    2018
  • 负责人：
    SHIMIZU Hidehisa
  • 依托单位：
    Shimane University
Analysis of relationships between the changing amount of skatole, an enterobacterium-derived dietary protein metabolite, and liver functions.
  • 批准号：
    25750356
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.66万
  • 财政年份：
    2013
  • 负责人：
    SHIMIZU Hidehisa
  • 依托单位：
    Hokkaido University
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