The effect of exercise and diosgenin induced increase of sex steroid hormone on type 2 diabetes

在研究1中，急性脱氢表雄酮（DHEA）给药改善了链脲佐菌素（STZ）诱导的1型糖尿病大鼠的高血糖。薯蓣皂苷元是一种结构上与脱氢表雄酮（DHEA）相似的甾体化合物，然而，薯蓣皂苷元是否通过增加肌肉GLUT4信号通路改善1型糖尿病模型大鼠的高血糖仍不清楚。结果，薯蓣皂苷元注射液降低血糖水平。此外，薯蓣皂苷元和薯蓣皂苷元均能显著增加2型糖尿病大鼠的GLUT4转位，以及Akt和PKC的磷酸化水平。8-每周服用薯蓣皂苷元显著改善空腹血糖水平和胰岛素抵抗。因此，薯蓣皂苷元给药可能是1型和2型糖尿病的新的治疗候选者。

In study 1, acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Diosgenin, a steroid structurally similar to DHEA (dehydroepiandrosterone), however, it is still unclear whether diosgeninimproves hyperglycemia in the type 1 diabetes model rats through an increase muscular GLUT4 signaling. As a result, diosgenin injections decreased blood glucose level. Moreover, GLUT4 translocation, as well as phosphorylation of Akt and PKC, increased significantly by diosgenin or dioscorea administration.In study 2, we determined whether chronic diosgenin administration improve insulin resistance in type 2 diabetes model rat. 8-week diosgenin administration significantly improved fasting blood glucose level and insulin resistance. Accordingly, diosgenin administration may be possible new therapetic candidates for type 1 and 2 diabetes.