Experimental study for clarifying the aggravating effects of Asian stand dust on Japanese cedar pollinnosis using β-glucan of amold

流行病学研究表明，亚洲沙尘（ASD）事件与儿童和成人哮喘和变应性鼻炎（包括杉木授粉病）的增加同时发生。风传ASD含有多种微生物因子，如细菌、真菌、真菌孢子和病毒。然而，真菌中提取的β-葡聚糖等微生物物质对杉木授粉病的影响尚不清楚。最近从ASD气溶胶中分离出一种真菌Bjerkandera adusta。本实验研究了真菌Bjerkandera （Bjer）和加热(H)-ASD对BAL/c雌性小鼠杉木花粉（Cryj1）诱导的变应性鼻炎的加重作用。Bjer本身引起过敏性鼻炎。Bjer+H-ASD共暴露可增强cryj1诱导的变应性鼻炎。这些结果表明，β-葡聚糖与ASD可能在杉木授粉病的恶化中起重要作用。

Epidemiologic studies have shown that Asian sand dust (ASD) events coincided with an increase in child and adult asthma and allergic rhinitis including Japanese cedar pollinosis.The wind-borne ASD contains various microbial agents, such as bacteria, fungi, fungal spores, and viruses. However, it is unclear the effects of microbial materials like β-glucan derived from fungi on Japanese cedar pollinosis.Recently Bjerkandera adusta, which is a fungus, was isolated from ASD aerosol. In this study,the exacerbating effects of the fungus, Bjerkandera (Bjer) and heated (H)-ASD on Japanese cedar pollen (Cryj1)-induced allergic rhinitis were investigated in BAL/c female mice. Bjer, itself caused allergic rhinitis. The Cryj1-induced allergic rhinitis was enhanced by co-exposure of Bjer+H-ASD.These results suggest that β-glucan together with ASD may play an important role in the aggravation of Japanese cedar pollinosis.