Experimental study for clarifying the aggravating effects of Asian stand dust on Japanese cedar pollinnosis using β-glucan of amold

利用amold的β-葡聚糖阐明亚洲立尘对日本柳杉花粉病的加重作用的实验研究

• 批准号: 23710046
• 负责人: HE Miao
• 金额: $ 2.16万
• 依托单位: Oita University of Nursing and Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710046/
• 关键词: スギ花粉症; β-グルカン; 黄砂; アレルギー性鼻炎; マウス; Cryj1; ベルカンデラ; 好酸球; βーグルカン; ビルカンデラ

Epidemiologic studies have shown that Asian sand dust (ASD) events coincided with an increase in child and adult asthma and allergic rhinitis including Japanese cedar pollinosis.The wind-borne ASD contains various microbial agents, such as bacteria, fungi, fungal spores, and viruses. However, it is unclear the effects of microbial materials like β-glucan derived from fungi on Japanese cedar pollinosis.Recently Bjerkandera adusta, which is a fungus, was isolated from ASD aerosol. In this study,the exacerbating effects of the fungus, Bjerkandera (Bjer) and heated (H)-ASD on Japanese cedar pollen (Cryj1)-induced allergic rhinitis were investigated in BAL/c female mice. Bjer, itself caused allergic rhinitis. The Cryj1-induced allergic rhinitis was enhanced by co-exposure of Bjer+H-ASD.These results suggest that β-glucan together with ASD may play an important role in the aggravation of Japanese cedar pollinosis.

流行病学研究表明，亚洲沙尘（ASD）事件与儿童和成人哮喘和过敏性鼻炎（包括日本雪松花粉症）的增加相一致。风传播的ASD含有各种微生物因子，如细菌，真菌，真菌孢子和病毒。然而，真菌来源的β-葡聚糖等微生物物质对柳杉花粉症的影响尚不清楚。在这项研究中，在BAL/c雌性小鼠中研究了真菌Bjerkandera（Bjer）和加热的（H）-ASD对日本雪松花粉（Cryj 1）诱导的过敏性鼻炎的加重作用。Bjer本身引起过敏性鼻炎。Bjer+H-ASD联合暴露可增强Cryj 1诱导的变应性鼻炎，提示β-葡聚糖和ASD可能在日本雪松花粉症的加重中起重要作用。