The roles of DNA repair genes during the mammary gland development and radiation-induced mammary tumorigenesis

在本研究中，我们得到的结果表明，在发育的乳腺中，DNA损伤反应的差异以及DNA修复基因BRIP1在促进正常的腺泡形态发生中具有重要作用，而BRIP1的缺失可能通过多个细胞信号通路的失调来扰乱腺泡的形成。由于BRIP1基因在电离辐射诱导的大鼠乳腺肿瘤中的表达水平降低，BRIP1可能在辐射诱导的乳腺肿瘤发生中发挥重要作用。

In this study, we obtained results suggesting that the differences in DNA damage response in developing mammary glands, and the DNA repair gene BRIP1 has important roles in promoting normal acinar morphogenesis and loss of BRIP1 disrupts acinar formation possibly through the dysregulation of multiple cellular signaling pathways. Since the expression levels of BRIP1 gene are reduced in rat mammary tumors-induced by ionizing radiation, BRIP1 may play important roles in radiation-induced mammary tumorigenesis.