Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosis

阐明Nrf-2激活剂鼠尾草酸调控肝细胞凋亡的分子机制

• 批准号: 24590992
• 负责人: WANG TING
• 金额: $ 3.49万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590992/
• 关键词: カルノシン酸; シグナル; アポトーシス; 酸化ストレス; 細胞死; Carnosic acid; Nrf2; Oxidative stress

项目成果

Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.

• DOI: 10.1371/journal.pone.0083264
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wang T;Kusudo T;Takeuchi T;Yamashita Y;Kontani Y;Okamatsu Y;Saito M;Mori N;Yamashita H
• 通讯作者: Yamashita H

Carnosic acid prevents lipid accumulation in hepatocytes through EGF/MAPK pathway

鼠尾草酸通过 EGF/MAPK 途径防止肝细胞脂质积累

• 发表时间: 2012
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Wang T;Takikawa Y;Tabuchi T;Kosaka K;Satoh T;Suzuki K. .
• 通讯作者: Suzuki K. .

Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation

• DOI: 10.1007/s00535-013-0927-6
• 发表时间: 2014-02
• 期刊: Journal of Gastroenterology
• 影响因子: 6.3
• 作者: Ting Wang;Y. Takikawa;A. Watanabe;Keisuke Kakisaka;Kanta Oigawa;Y. Miyamoto;Kazuyuki Suzuki

Carnosic acid protects against oxidative stress-induced cytotoxicity in primary hepatocytes, induces tumor cell death, and inhibits TGFβ-induced migration and invasion in HepG2 cells.

Carnosic Acid 可防止原代肝细胞中氧化应激诱导的细胞毒性，诱导肿瘤细胞死亡，并抑制 TGFβ 诱导的 HepG2 细胞迁移和侵袭。

• 发表时间: 2013
• 作者: Takikawa Y、Wang T;Watanabe A;Kakisaka K;Onodera M;Oikawa K.
• 通讯作者: Oikawa K.

Negative Regulation of Human Astrocytes by Interferon (IFN) α in Relation to Growth Inhibition and Impaired Glucose Utilization

• DOI: 10.1007/s11064-012-0806-1
• 发表时间: 2012-05
• 期刊: Neurochemical Research
• 影响因子: 4.4
• 作者: Ting Wang;Y. Takikawa;K. Sawara;Y. Yoshida;Kazuyuki Suzuki