Contribution of chemokines and growth factors for the cervical lymph node metastasis in oral squamous cell carcinoma
Contribution of chemokines and growth factors for the cervical lymph node metastasis in oral squamous cell carcinoma
批准号:
24792206
负责人:
TANAKA Noriaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
One of prognostic factors of oral squamous cell carcinoma patients is cervical lymph node metastasis. In this study, we analyzed the factors of lymph node metastasis to use with resected tissues and cultured cells of oral cancer. From the results of analysis for resected tissues, we found the correlation between cervical lymph node metastasis and highly expression of VEGF-C or CCR7 in cancer cells. Moreover, from the results of analysis for cultured cells, VEGF-C promotes cancer cells migration and invasion abilities. Thus, VEGF-C induces lymphangiogenesis in peritumoral tissue and promotes migration and invasion abilities in oral cancer. Moreover, it is suggested that oral cancer cells are promoted cervical lymph node metastasis to enhance invasion into lymphatic vessels by chamotaxis of CCR7-CCL19 lineage.
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DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[山本奈穂, 相川友直, 田中徳昭, 沢井奈津子, 山田謙一, 應谷昌隆, 古郷幹彦, 大倉正也]
通讯作者:
大倉正也
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口腔癌远处转移危险因素的统计研究
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--
发表时间:
2012
期刊:
影响因子:
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作者:
[田中徳昭, 大倉正也, 相川友直, 山田謙一, 應谷昌隆, 松賀ひとみ, 古郷幹彦]
通讯作者:
古郷幹彦
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Yamamoto N, Otani M, Yamada K, Tanaka N, Aikawa T, Okura M and Kogo M]
通讯作者:
Okura M and Kogo M
DOI:
10.3892/ijo.2011.1258
发表时间:
2012-04
期刊:
International journal of oncology
影响因子:
5.2
作者:
[Ishimoto S, Wada K, Tanaka N, Yamanishi T, Ishihama K, Aikawa T, Okura M, Nakajima A, Kogo M, Kamisaki Y]
通讯作者:
Kamisaki Y
当科における口腔癌周術期栄養療法 EPAとProbioticsの併用効果について
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DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[平岡慎一郎,伊藤章, 森本泰成, 内橋俊大, 沢井奈津子, 相川友直, 大倉正也, 古郷幹彦, 平岡慎一郎,田中徳昭,大倉正也,古郷幹彦]
通讯作者:
平岡慎一郎,田中徳昭,大倉正也,古郷幹彦
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総合ビタミン製剤の連続投与が高度腎機能障害患者に及ぼす影響の解明
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批准号:19H00350
-
项目类别:Grant-in-Aid for Encouragement of Scientists
-
资助金额:$0.35万
-
财政年份:2019
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负责人:TANAKA Noriaki
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依托单位:
The relationship of MMPs and growth factors in the invasion mechanism of adenoid cystic carcinoma
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批准号:20791561
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
-
财政年份:2008
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负责人:TANAKA Noriaki
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依托单位:
Hepatic differentiation of human embryonic stem cells and its application to the development of a bioartificial liver system
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批准号:19390334
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:TANAKA Noriaki
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依托单位:
Elucidation, of the interacting mechanism between epigenetic and genetic alterations in gastrointestinal cancers and of the possible application to the clinic
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批准号:17390368
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.92万
-
财政年份:2005
-
负责人:TANAKA Noriaki
-
依托单位:
Development of Regenerative Medicine Using Reversibly Proliferating Human Bone Marrow Mesenchymal Stem Cells
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批准号:15390378
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.41万
-
财政年份:2003
-
负责人:TANAKA Noriaki
-
依托单位:
Bioartificial liver development using reversibly immortalized human liver cell lines.
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批准号:13470236
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.56万
-
财政年份:2001
-
负责人:TANAKA Noriaki
-
依托单位:
Cell cycle transactivation factor E2F-4 is associate with the ganstrointestinal carcinogenesis and/or acquisition of chemoresistance
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批准号:11671237
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:1999
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负责人:TANAKA Noriaki
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依托单位:
Role of ornithine decarboxylase (ODC) as a oncogene in colorectal tumorigenesis
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批准号:08671368
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.45万
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财政年份:1996
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负责人:TANAKA Noriaki
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依托单位:
THE IMMUNOLOGICAL HYPORESPONSIVENESS AND DONOR CELL PERSISTENCE IN HOST LIVER AFER PORTAL VENOUS INNOCULATION
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批准号:06671205
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1994
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负责人:TANAKA Noriaki
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依托单位:
Studies on the functions of the actirated lymphocytes after partial hepatectomy
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批准号:60480293
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.24万
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财政年份:1985
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负责人:TANAKA Noriaki
-
依托单位:
海外基金