The relationship of MMPs and growth factors in the invasion mechanism of adenoid cystic carcinoma

MMPs与生长因子在腺样囊性癌侵袭机制中的关系

• 批准号: 20791561
• 负责人: TANAKA Noriaki
• 金额: $ 2.66万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791561/
• 关键词: 腺様嚢胞癌; 3次元培養; 浸潤機構; MMPs; 増殖因子

Adenoid cystic carcinoma is a malignant salivary gland tumor characterized by perineural and perivascular invasion. In this study, we found that MMP9 and MMP14 were associated with the invasion mechanism of adenoid cystic carcinoma. In addition, the expression of VEGF was found in the adenoid cystic carcinoma cells, and it was suggested that VEGF induced angiogenesis at peritumoral stroma. Furthermore, it might be thought that semaphorins, which were known as the neuron guidance factor, were associated with the invasion mechanism of adenoid cystic carcinoma.

腺样囊性癌是一种以神经和血管周围浸润为特征的涎腺恶性肿瘤。在本研究中，我们发现MMP 9和MMP 14与腺样囊性癌的侵袭机制有关。另外，在腺样囊性癌细胞中发现VEGF的表达，提示VEGF可诱导瘤周间质的血管生成。此外，脑信号蛋白作为一种神经元导向因子，可能与腺样囊性癌的侵袭机制有关。

项目成果

Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of head and neck

头颈部腺样囊性癌CXCR4表达与组织学形态及转移潜能的关系

• 发表时间: 2008
• 期刊: Int. J Oncol. 33
• 作者: Zushi Y;Noguchi K;Hashitani S;Sakurai K;Segawa E;Takaoka K;Toyohara Y;Tanaka N;Kishimoto H;Urade M
• 通讯作者: Urade M

histological patterns, and metastatic potential in adenoid cystic carcinoma of head and neck

头颈部腺样囊性癌的组织学模式和转移潜力

• 发表时间: 2008
• 期刊: CXCR4 vol.33
• 作者: Zushi Y;Noguchi K;Hashitani S;Sakurai K;Segawa E;Takaoka K;Toyohara Y;Tanaka N;Kishimoto H;Urade M
• 通讯作者: Urade M

Establishment of a novel adenoid cystic carcinoma cell line in the salivary gland

唾液腺中新型腺样囊性癌细胞系的建立

• 发表时间: 2008
• 作者: Zushi Y;Noguchi K;Hashitani S;Sakurai K;Segawa E;Takaoka K;Toyohara Y;Tanaka N;Kishimoto H;Urade M;Tanaka N
• 通讯作者: Tanaka N