Construction of catalytic reaction space based on membrane domain

在自然界中创建像光合作用这样的多功能反应系统是相当令人感兴趣的。 虽然已经研究了由聚合物和蛋白质组成的各种化学反应器，但是仍然难以构建其中同时发生不同化学反应的反应系统。 我们专注于脂质体，这是一个人工制备的球形囊泡组成的磷脂的脂双层，作为化学反应空间。 为了将功能分子定点固定到脂质体空间中，我们使用对磷脂具有高亲和力的胆固醇衍生物设计了功能亲脂单元，并成功地固定了各种功能分子，如光敏剂，捕光色素和氧化催化剂。 利用功能性亲脂单元，研究了脂质体空间中的电子转移反应、能量转移反应和催化反应。

Creation of multifunctional reaction systems like photosynthesis in nature is of considerable interest. Although various chemical reactors consisting of polymers and proteins have been studied, it is still difficult to construct reaction systems in which different chemical reactions occur simultaneously. We focus on a liposome, which is an artificially-prepared spherical vesicle composed of a lipid bilayer of phospholipids, as a chemical reaction space. For the site-specific fixation of functional molecules into liposome space, we designed functional lipophilic units using a cholesterol derivative which has high affinity for phospholipids, and succeeded in the fixation of various functional molecules such as photosensitizers, light-harvesting pigments and oxidation catalysts. Electron transfer reaction, energy transfer reaction and catalytic reaction in liposome space have been demonstrated using functional lipophilic units.