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Analysis for role of calumin in lipid transport of polarized cells

Analysis for role of calumin in lipid transport of polarized cells
钙铝在极化细胞脂质转运中的作用分析
批准号：
24790073
负责人：
YAMAMOTO Shinichiro
金额：
$2.91万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790073/
关键词：
ERADER ストレス

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英文摘要
Calumin is a novel ER-resident protein. Disruption of calumin gene in mice causes embryonic lethality, suggesting that calumin plays the indispensable physiological role. But, the physiological role of calumin is not clear.To maintain ER homeostasis, ER is equipped with ERAD functioning as protein quality control system. This study suggests not only the importance of calumin in ERAD but also the significance of ERAD in visceral endoderm cells functioning as the very few secretory cells around the embryonic day when calumin-knockout mice die.
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