Analysis for role of calumin in lipid transport of polarized cells

钙铝在极化细胞脂质转运中的作用分析

• 批准号: 24790073
• 负责人: YAMAMOTO Shinichiro
• 金额: $ 2.91万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790073/
• 关键词: ERAD; ER ストレス

Calumin is a novel ER-resident protein. Disruption of calumin gene in mice causes embryonic lethality, suggesting that calumin plays the indispensable physiological role. But, the physiological role of calumin is not clear.To maintain ER homeostasis, ER is equipped with ERAD functioning as protein quality control system. This study suggests not only the importance of calumin in ERAD but also the significance of ERAD in visceral endoderm cells functioning as the very few secretory cells around the embryonic day when calumin-knockout mice die.

Calumin是一种新的内质网驻留蛋白。钙调蛋白基因的突变导致小鼠胚胎死亡，提示钙调蛋白在胚胎发育中起着不可或缺的生理作用。钙调蛋白的生理作用尚不清楚，为了维持内质网的稳态，内质网内配备了ERAD作为蛋白质质量控制系统。这项研究不仅表明钙蛋白在ERAD中的重要性，而且还表明ERAD在内脏内胚层细胞中的重要性，这些细胞在钙蛋白敲除小鼠死亡的胚胎日周围起着非常少的分泌细胞的作用。