Analysis for physiological role of the Ca2+-binding ER protein calumin

Calumin是内质网上的跨膜蛋白。虽然在小鼠中敲除诽谤蛋白在E10左右是胚胎致死的。5-11。5、生理作用不明确。因此，我们研究了诈骗蛋白的生理作用。Calumin在卵黄囊内胚层细胞中特异表达，卵黄囊内胚层细胞是主要的营养运输细胞。此外，卵黄囊内胚层细胞中有脂滴积聚。因此，推测Calumin参与了内胚层细胞的脂质转运。

Calumin is transmembrane protein on endoplasmic reticulum. Although calumin knockout in mice is embryonic lethal around E10. 5-11. 5, the physiological role is no clear. Thus, we investigated the physiological role of calumin. Calumin is specifically expressed in yolk sac endoderm cells which are the principal nutrient-transporting cells. Additionally, lipid droplets are accumulated in calumin knockout yolk sac endoderm cells. Therefore, it was suggested that calumin was involved in lipid transport in endoderm cells.