Control of polyglutamine protein aggregation by eEF1BdeltaL

在以前的研究中，我们已经发现eEF1BdeltaL是一种新的参与应激反应的脑特异性转录因子。在本研究中，为了探讨eEF1BdeltaL在多发性谷氨酰胺病的病理生理中的作用，进行了几个实验。然而，eEF1BdeltaL对聚谷氨酰胺蛋白聚集的影响还没有得到明显的证据。然后检测eEF1 BdeltaL基因敲除小鼠的表型。这些小鼠发育正常，但在学习行为方面表现出缺陷。因此，eEF1BdeltaL参与了成年期脑功能尤其是学习记忆的调节。

In previous study, we have found that eEF1BdeltaL is a new brain-specific transcriptional factor involved in stress responses. In this study, to investigate the role of eEF1BdeltaL in the pathophysiology of polyglutamine diseases, several experiments were done. However, obvious evidence that eEF1BdeltaL influences on polyglutamine protein aggregation has not been obtained. Then the phenotype of eEF1BdeltaL knockout mice was examined. These mice developed normally, but showed deficits in learning behavior. Therefore, it is suggested that eEF1BdeltaL is involved in the brain function especially learning and memory in the adulthood.