The roles of nuclear IkappaB protein in the regulation of B cell function

转录因子核因子- kappab （NF-kappaB）在免疫系统和炎症反应的整体调节中起着重要作用。NF-kappaB的激活受到IkappaB抑制蛋白的严格调控，IkappaB由经典的细胞质和细胞核IkappaB组成。研究了NF-kappaB核调节因子IkappaBNS在B细胞发育和功能中的作用。我们发现IkappaBNS对增殖活性和通过toll样受体信号产生抗体很重要。IkappaBNS还参与产生抗炎细胞因子IL-10的调节性B细胞的发育。因此，IkappaBNS在控制免疫反应中的另一个重要作用被确定。

A transcription factor nuclear factor-kappaB (NF-kappaB) plays an essential role in the overall regulation of the immune system and inflammatory responses. Activation of NF-kappaB is tightly regulated by inhibitory proteins termed IkappaB, which consist of classical cytoplasmic and nuclear IkappaBs. Roles of a nuclear regulator of NF-kappaB, IkappaBNS, in the development and function of B cells were studied. We have found that IkappaBNS is important for proliferative activity and antibody production via Toll-like receptor signals. IkappaBNS is also involved in the development of regulatory B cells that produce anti-inflammatory cytokine IL-10. Thus, an additional important role for IkappaBNS in control of the immune response was defined.