Validation of the presence of myeloid-B progenitor stage towards to B cells on the differentiation pathway of hematopoiesis

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We have proposed a model of hematopoiesis in which myeloid potential is retained along with the developmental pathway towards to T, B and erythroid lineages. In this project, we aimed to validate the presence of myeloid-B progenitors on the way from multipotent progenitors towards to B cells using co-culture system with stromal cells. We found that pre-pro B cells still retain the myeloid potential while hardly maintaining T cell potential, and that proB cells terminate the differentiation potential to other lineages. These results substantiate that the myeloid-B progenitor stage exist on the differentiation pathway towards to B cells. This project has been successfully achieved.