Dose-effect relationship between heavy-metal exposure levels and oxidative stress markers in heavy-metal exposed workers

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The aim of this study was to investigate the dose-effect relationships between heavy metal exposure and oxidative stress markers. The subjects were 27 male workers in a lead secondary smelting factory, and 59 workers exposed to indium metal or indium compounds. Lead in whole blood (Pb-B) or indium in serum (In-S) was measured as an exposure index of lead or indium. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and urinary 8-isoprostaglandin F2 alpha(8-iso-PGF) were determined as a DNA peroxidation stress marker and as a cell membrane peroxidation stress biomarker.Significant exposure-effect relationships were observed between Pb-B and 8-OHdG, and between Pb-B and 8-iso-PGF. Lead exposure may induce peroxidation stress on DNA and cell membrane lipid. Conversely, there were no significant relationships between In-S and two biomarkers.