Dose-effect relationship between heavy-metal exposure levels and oxidative stress markers in heavy-metal exposed workers

本研究的目的是探讨重金属暴露与氧化应激标志物之间的剂量-效应关系。受试者是一家铅二次冶炼厂的27名男工，以及59名接触金属铟或铟化合物的工人。测定全血铅(PbB)或血清铟(In-S)作为铅或铟的暴露指标。以尿8-羟基脱氧鸟苷(8-OHdG)和尿8-异前列腺素F2α(8-iso-PGF)作为DNA过氧化应激标志物和细胞膜过氧化应激生物标志物，发现铅-B与8-OHdG、8-iso-PGF之间存在显著的暴露效应关系。铅暴露可引起DNA和细胞膜脂质过氧化应激。相反，In-S与两个生物标志物之间没有显著的关系。

The aim of this study was to investigate the dose-effect relationships between heavy metal exposure and oxidative stress markers. The subjects were 27 male workers in a lead secondary smelting factory, and 59 workers exposed to indium metal or indium compounds. Lead in whole blood (Pb-B) or indium in serum (In-S) was measured as an exposure index of lead or indium. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and urinary 8-isoprostaglandin F2 alpha(8-iso-PGF) were determined as a DNA peroxidation stress marker and as a cell membrane peroxidation stress biomarker.Significant exposure-effect relationships were observed between Pb-B and 8-OHdG, and between Pb-B and 8-iso-PGF. Lead exposure may induce peroxidation stress on DNA and cell membrane lipid. Conversely, there were no significant relationships between In-S and two biomarkers.