Dose-effect relationship between heavy-metal exposure levels and oxidative stress markers in heavy-metal exposed workers

重金属暴露工人重金属暴露水平与氧化应激标志物的量效关系

• 批准号: 24790591
• 负责人: IWASAWA Satoko
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790591/
• 关键词: 産業中毒; 酸化ストレスマーカー; 血液中鉛; 血清インジウム; 量影響関係; 8-iso-PGF; 8-OHdG; 金属インジウム; インジウム化合物; 鉛; 産業疫学; 量反応関係; 重金属曝露

The aim of this study was to investigate the dose-effect relationships between heavy metal exposure and oxidative stress markers. The subjects were 27 male workers in a lead secondary smelting factory, and 59 workers exposed to indium metal or indium compounds. Lead in whole blood (Pb-B) or indium in serum (In-S) was measured as an exposure index of lead or indium. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and urinary 8-isoprostaglandin F2 alpha(8-iso-PGF) were determined as a DNA peroxidation stress marker and as a cell membrane peroxidation stress biomarker.Significant exposure-effect relationships were observed between Pb-B and 8-OHdG, and between Pb-B and 8-iso-PGF. Lead exposure may induce peroxidation stress on DNA and cell membrane lipid. Conversely, there were no significant relationships between In-S and two biomarkers.

本研究旨在探讨重金属暴露与氧化应激指标之间的剂量效应关系。研究对象为某铅二次冶炼厂27名男工和59名接触金属铟或铟化合物的工人。测定全血铅（Pb-B）或血清铟（In-S）作为铅或铟的暴露指数。尿8-羟基脱氧鸟苷（8-OHdG）和尿8-异前列腺素F_（2 α）（8-iso-PGF）作为DNA过氧化应激标志物和细胞膜过氧化应激标志物，Pb-B与8-OHdG和8-iso-PGF之间存在显著的量效关系。铅暴露可引起DNA和细胞膜脂质过氧化损伤。相反，In-S和两种生物标志物之间没有显著关系。

项目成果

鉛曝露作業服務者における血液中鉛と尿中酸化ストレスマーカーの関係

铅作业工人血铅与尿氧化应激标志物的关系

• 发表时间: 2013
• 期刊: 健康開発
• 作者: 大日方謙介,賀陽智之,岩澤聡子,細田加那江,大前和幸

鉛曝露作業服務者における血液中鉛と尿中酸化ストレスマーカーの関係：パイロット研究

铅暴露工人血铅与尿氧化应激标志物之间的关系：一项初步研究

• 发表时间: 2013
• 期刊: 健康開発
• 作者: 大日方謙介;賀陽智之;岩澤聡子;細田加那江;大前和幸
• 通讯作者: 大前和幸