Evolution of a pathogen resistance pathway in the tomato genus

番茄属病原体抗性途径的进化

• 批准号: 5437929
• 负责人: Professorin Dr. Laura Rose
• 金额: --
• 依托单位: Institut Populationsgenetik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5437929?language=en
• 关键词: Evolution; pathogen; resistance; pathway; tomato

In this project, we will investigate the selective forces that have shaped the evolution of five genes involved in resistance to a bacterial pathogen of tomato, Pseudomonas syringae pv. tomato. One of these genes, Pto, has been identified as the receptor for the pathogen ligand. Another gene, Prf, ist closely linked to Pto and is required for activating the resistance response once the pathogen has been detected. The other three genes encode proteins which physically interact with Pto and contribute to plant disease resistance. Our study will focus on DNA sequence variation in a natural population of the self-incompatible species, Lycopersicon peruvianum. Since these genes are involved in the same pathway, we will evaluate how position in pathway influences the selective constraints acting on these genes. Using linkage disequilibrium analysis, we will also determine if Pto and Prf show correlated evolution, as may be expercted due to their physical linkage and/or functional interaction.

在这个项目中，我们将研究形成五个基因进化的选择性力量，这些基因与番茄对细菌病原菌Pseudomonas syringae PV的抗性有关。番茄。其中一个基因PTO已被确定为病原体配体的受体。另一个基因prf与PTO紧密连锁，一旦检测到病原菌就需要激活抗性反应。其他三个基因编码的蛋白质与PTO物理上相互作用，有助于植物抗病。我们的研究将集中在自交不亲和的番茄自然种群中的DNA序列变异。由于这些基因涉及同一途径，我们将评估途径中的位置如何影响作用于这些基因的选择性约束。利用连锁不平衡分析，我们还将确定PTO和PRF是否表现出相关的进化，这可能是由于它们的物理连锁和/或功能相互作用所致。