ピクセル型放射線検出器を用いた動的適応小線源治療システムの開発

使用像素型辐射探测器开发动态自适应近距离治疗系统

• 批准号: 16J04075
• 负责人: Tran Thi Thao Nguyen (2017-2018)
• 金额: $ 1.6万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-22 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J04075/
• 关键词: Cold spots; IMRT; VMAT; Prostate cancer; Cervical cancer; Brachytherapy; Heterogeneous materials; Monte Carlo simulation; 3D gamma analysis; Applicator

Small volumes of low dose regions (cold spots) in the target volume in prostate cancer treatment could cause recurrence of tumors. This study aimed to compare volumetric-modulated arc therapy (VMAT) with intensity-modulated radiation therapy (IMRT) accounting for cold spots in prostate cancer plans. The basic idea was to evaluate dosimetric indices for the planning target volume (PTV) and organs at risk (OAR), and analyze cold spots (numbers and volumes) of the PTV and the region in which the rectum overlapped with the PTV (ROP) region for VMAT and IMRT plans. Three-dimensional probabilistic distributions of cold spots were also generated using a centroid matching technique for visualization and analysis. The differences between the VMAT and IMRT plans were evaluated using two-sided paired Student’s t-test. Compared with IMRT, the VMAT plans achieved better PTV dose conformity, OAR dose-sparing, and smaller cold spots in the treatment of prostate cancer.This research has been published in the Radiological Physics and Technology (RPT), 2019.02, (https://doi.org/10.1007/s12194-019-00502-0).

在前列腺癌治疗中，靶体积中的小体积低剂量区域（冷点）可能导致肿瘤复发。本研究旨在比较体积调强弧形放射治疗（VMAT）与调强放射治疗（IMRT）在前列腺癌计划中的冷点。其基本思想是评估计划靶区（PTV）和危及器官（OAR）的剂量学指标，并分析VMAT和IMRT计划中PTV和直肠与PTV（ROP）重叠区域的冷点（数量和体积）。冷点的三维概率分布也产生了可视化和分析使用的质心匹配技术。使用双侧配对Student t检验评价VMAT和IMRT计划之间的差异。与IMRT相比，VMAT计划在前列腺癌治疗中实现了更好的PTV剂量符合性，OAR剂量节省和更小的冷点。该研究已发表在放射物理与技术（RPT），2019.02，（https：//doi.org/10.1007/s12194-019-00502-0）。

项目成果

有村研究室

有村研究所

Monte Carlo Simulations Analysis of Dosimetric Impacts of Titanium Applicator and Tissue Inhomogeneity of Cervical Intracavitary Brachytherapy

钛施用器剂量影响和颈腔内近距离放射治疗组织不均匀性的蒙特卡罗模拟分析

• 发表时间: 2017
• 期刊: Japanese Journal of Medical Physics
• 作者: Tran Thi Thao Nguyen;Hidetaka Arimura;Yoshifumi Oku;Takahiro Iwasaki;Takashi Yoshiura
• 通讯作者: Takashi Yoshiura

Monte Carlo based Assessment of Impacts of Heterogeneous Materials on Dose Distributions using Three-dimensional Gamma Analysis in Intracavitary Brachytherapy for Cervical Cancer

基于蒙特卡罗的宫颈癌腔内近距离放射治疗中使用三维伽玛分析来评估异种材料对剂量分布的影响

• 发表时间: 2016
• 作者: Tran Thi Thao Nguyen;Hidetaka Arimura;Yoshifumi Oku;Takashi Yoshiura,
• 通讯作者: Takashi Yoshiura,

Impacts of inhomogeneous materials in intracavitary brachytherapy for cervical cancer

不均匀材料对宫颈癌腔内近距离放射治疗的影响

• 发表时间: 2018
• 期刊: Hope Meeting with Nobel Laureates
• 作者: Tran Thi Thao Nguyen;Hidetaka Arimura
• 通讯作者: Hidetaka Arimura

Analysis of influence of tissue heterogeneity on dose distribution in intracavitary treatment of cervix carcinoma on 3D treatment planning

宫颈癌腔内治疗组织异质性剂量分布对3D治疗计划的影响分析

• 发表时间: 2016
• 期刊: Japanese Journal of Medical Physics
• 作者: Takahiro Iwasaki;Hidetaka Arimura;Tran Thi Thao Nguyen;et al.
• 通讯作者: et al.