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Schistosoma mansoni: Molecular genetic effects following inhibitor treatment; functional characterization of differentially expressed genes potentially involved in regulating mitoses and egg-formation processes

曼氏血吸虫：抑制剂治疗后的分子遗传效应；

基本信息

批准号：
61478608
负责人：
Professor Dr. Christoph G. Grevelding
金额：
--
依托单位：
Biomedizinisches Forschungszentrum Seltersberg (BFS)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2008
资助国家：
德国
起止时间：
2007-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/61478608?language=en
关键词：
Schistosoma mansoni Molecular genetic effects

项目摘要

Schistosome parasites cause schistosomiasis (bilharzia), an infectious disease of worldwide significance. Due to the success of international genome sequencing projects we actually have access to nearly complete genome and transcriptome data of different schistosome species. We intend to use these data for experimental approaches to investigate the effect of chemical inhibitors on molecular processes of adult schistosomes. One peculiarity of the biology of these parasites is the male-dependent sexual development of the female. A constant pairing contact with the male is necessary to induce mitoses and differentiation processes in the female leading to fully developed reproductive organs. In previous studies we have demonstrated that Src kinase- and TGFβ signaling-pathways play essential roles in controlling mitogenic activity, differentiation, and egg production in the female. Using microarray technology we now want to analyze the molecular processes which lead to egg production, and which are influenced by the inhibition of these signaling molecules. Since the eggs are the causative agent for the pathology of schistosomiasis, this study will not only provide basic biological knowledge, but will also open novel perspectives for the design of required alternative strategies to fight schistosomes.

血吸虫病是一种世界性的传染性疾病。由于国际基因组测序项目的成功，我们实际上已经获得了几乎完整的不同血吸虫物种的基因组和转录组数据。我们打算利用这些数据为实验方法研究化学抑制剂对成虫分子过程的影响。这些寄生虫的生物学特性之一是雌性的性发育依赖于雄性。与雄性的持续配对接触是诱导雌性有丝分裂和分化过程的必要条件，从而导致生殖器官的完全发育。在之前的研究中，我们已经证明Src激酶-和tgf - β信号通路在控制雌性有丝分裂活性、分化和产卵中起重要作用。利用微阵列技术，我们现在想分析导致卵子产生的分子过程，以及受这些信号分子抑制的影响。由于虫卵是血吸虫病病理的致病因子，本研究不仅将提供基本的生物学知识，而且将为设计所需的抗血吸虫替代策略开辟新的视角。