MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI

曼索尼血吸虫基因组和表面的分子研究

• 批准号: 3803120
• 负责人: A SHER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3803120
• 关键词: Bacillus Calmette Guerin vaccine; Mycobacterium bovis; Schistosoma mansoni; T lymphocyte; anthelmintics; gene expression; genetic markers; helminthic antigen; microorganism immunology; molecular cloning; molecular genetics; parasitic disease chemotherapy; schistosomiasis; vaccines

The aim of this project is to characterize schistosome molecules relevant to immunity and pathogenesis, to analyze the molecular basis of physiologically important parasite processes which could serve as targets for intervention, and to develop and test recombinant vaccines. Progress was achieved in the following areas: A. Testing of BCG-paramyosin recombinants. The immune response stimulated by a vaccine recombinant produced by cloning paramyosin into BCG was characterized. B. Identification of recombinant clones expressing epitopes reactive with vaccine T cells. Clones from an expression library were screened against T cells from vaccinated mice in order to identify potential new immunogens.

本项目的目的是表征血吸虫相关分子