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MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI

MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
曼索尼血吸虫基因组和表面的分子研究
批准号：
3803120
负责人：
A SHER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3803120
关键词：
Bacillus Calmette Guerin vaccine Mycobacterium bovis Schistosoma mansoni T lymphocyte anthelmintics gene expression genetic markers helminthic antigen microorganism immunology molecular cloning molecular genetics parasitic disease chemotherapy schistosomiasis vaccines

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中文摘要
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英文摘要
The aim of this project is to characterize schistosome molecules relevant to immunity and pathogenesis, to analyze the molecular basis of physiologically important parasite processes which could serve as targets for intervention, and to develop and test recombinant vaccines. Progress was achieved in the following areas: A. Testing of BCG-paramyosin recombinants. The immune response stimulated by a vaccine recombinant produced by cloning paramyosin into BCG was characterized. B. Identification of recombinant clones expressing epitopes reactive with vaccine T cells. Clones from an expression library were screened against T cells from vaccinated mice in order to identify potential new immunogens.
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会议论文
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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