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MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI

MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
曼索尼血吸虫基因组和表面的分子研究
批准号：
3809584
负责人：
A SHER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809584
关键词：
Bacillus Calmette Guerin vaccine Brazil Mycobacterium bovis Salmonella Schistosoma mansoni T lymphocyte animal population genetics anthelmintics cell bank /registry complementary DNA gene expression genetic manipulation genetic mapping genetic markers helminthic antigen leukocyte activation /transformation microorganism immunology molecular cloning molecular genetics nucleic acid probes nucleic acid sequence parasitic disease chemotherapy protein sequence restriction mapping schistosomiasis tropomyosin vaccines

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中文摘要
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英文摘要
The aim of this project is to characterize schistosome surface molecules relevant to immunity, to analyze the genome of the parasite in relation to specific biological properties of the organism and to clone important schistosome immunogens. A. Development of a paramyosin BCG recombinant cDNA's encoding paramyosin were cloned into BCG for vacome testing. B. Genetic analysis of natural schistosome populations. Using a rDNA probe, the genetic heterogeneity and geographic variation of a collection of S> mansoni isolates from Brazil was characterized. C. Creation of an expression clone bank for T epitope screening. A battery of 500 clones from a S. mansoni expression cDNA were selected for use in identifying important antigens recognized by T cells from vaccinated animals.
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会议论文
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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