Basic study for the development of totally implantable artificial heart.

随着全人工心脏临床应用的进步，人们迫切希望开发出一种完全可植入的人工心脏，使患者能够自由活动并重返工作岗位。本研究的目的是解决与全植入式人工心脏发展相关的各种基本问题。通过这三年的项目，可以取得以下成果1.结论：1.通过在胸壁放置血泵的全置换人工心脏，可成功地使山羊存活344天(世界最长存活纪录)。设计制作了一种新型植入式血泵，并成功地在山羊体内存活了2周。为了消除全植入型人工心脏系统中的顺应室，设计了各种类型的顺应性无腔血泵。制作了直流电机驱动的样机模型，取得了较好的性能。设计了一种以离心泵产生硅油流为驱动力的新型植入式人工心脏，并对其性能和能量传递效率进行了测试。根据这些数据构建下一步的模型。进行了经皮能量传递的基础实验。研究了线圈的形状、大小、绕组个数、一次、二次线圈间距、电压等级、频率与能量传输效率的关系。说明神经系统与TAH动物各种病理生理状态的发生密切相关。为了构建人工心脏的控制逻辑，研制了一种新型的自动可控驱动单元。为了寻找新的血液相容性材料，建立了一种新的血液相容性测试方法。

It is strongly desired to develop a totally implantable artificial heart by which patients can act freely and return to their job, according to the advancement of clinical use of the total artificial heart. The objective of this study is to solve the various basical problems accompanied with the development of totally implantable artificial heart. The following results could be obtained by this three years project.1. It could be succeeded to survive a goat for 344 days(World longest survival record) by total replacement artificial heart in which the blood pumps were placed on the chest wall.2. A new implantable blood pump was designed and fabricated, and succeeded to survive a goat for 2 weeks.3. To eliminate the compliance chamber from totally implantable artificial heart system, various types of compliance chamberless blood pump were designed. A prototype model driven by DC motor was made, which revealed a good performance.4. A new implantable artificial heart in which silicone oil flow was generated by centrifugal pump as driving force was designed, and its performance and energy transmission efficiency were measured. The next model are constructing by these data.5. Basical experiment of transcutaneous energy transmission were performed. Relation among shape, size and winding number of the coil, distance between primary and secondary coil, voltage level, frequency and enrgy transmission efficiency were investigated.6. It could be clarified that nervoussystem would be closely related to the generation of various pathophysiological state in TAH animals.7. A new automatically controllable driving unit was developed to construct a control logic of artificial heart.8. A new blood compatibility test method was developed to search new AH material.