Basic study for the development of totally implantable artificial heart.

全植入式人工心脏研制的基础研究。

• 批准号: 58440053
• 负责人: ATSUMI Kazuhiko
• 金额: $ 21.89万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1983
• 资助国家: 日本
• 起止时间: 1983 至 1985
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-58440053/
• 关键词: Artificial heart; Totally implantable artificial heart; Driving unit; Blood pump; Compliance chamber; Centrifugal pump; Energy transmission

It is strongly desired to develop a totally implantable artificial heart by which patients can act freely and return to their job, according to the advancement of clinical use of the total artificial heart. The objective of this study is to solve the various basical problems accompanied with the development of totally implantable artificial heart. The following results could be obtained by this three years project.1. It could be succeeded to survive a goat for 344 days(World longest survival record) by total replacement artificial heart in which the blood pumps were placed on the chest wall.2. A new implantable blood pump was designed and fabricated, and succeeded to survive a goat for 2 weeks.3. To eliminate the compliance chamber from totally implantable artificial heart system, various types of compliance chamberless blood pump were designed. A prototype model driven by DC motor was made, which revealed a good performance.4. A new implantable artificial heart in which silicone oil flow was generated by centrifugal pump as driving force was designed, and its performance and energy transmission efficiency were measured. The next model are constructing by these data.5. Basical experiment of transcutaneous energy transmission were performed. Relation among shape, size and winding number of the coil, distance between primary and secondary coil, voltage level, frequency and enrgy transmission efficiency were investigated.6. It could be clarified that nervoussystem would be closely related to the generation of various pathophysiological state in TAH animals.7. A new automatically controllable driving unit was developed to construct a control logic of artificial heart.8. A new blood compatibility test method was developed to search new AH material.

随着全人工心脏临床应用的发展，迫切需要开发一种完全可植入的人工心脏，通过该人工心脏，患者可以自由活动并返回工作岗位。本研究的目的是解决全植入式人工心脏发展过程中的各种基本问题。通过三年的项目研究，取得了以下成果：1.将血泵置于胸壁的全置换型人工心脏可使山羊成功存活344天（世界最长存活记录）.设计并制作了一种新型的植入式血泵，并成功地在山羊体内存活了2周.为了消除全植入式人工心脏系统中的顺应性腔，设计了各种类型的无顺应性腔血泵。制作了直流电机驱动的样机，样机性能良好.设计了一种以离心泵产生硅油流为驱动力的新型植入式人工心脏，并对其性能和能量传输效率进行了测试。接下来的模型是根据这些数据构建的.进行了经皮能量传输的基础实验。研究了线圈的形状、尺寸、匝数、一、二次线圈间距、电压等级、频率与能量传输效率的关系.说明神经系统与TAH动物各种病理生理状态的发生密切相关.研制了一种新型的自动可控驱动单元，构建了人工心脏的控制逻辑.为寻找新型AH材料，建立了一种新的血液相容性试验方法。