Reduction of Preserved Capacity for Skeletal Muscle with Aging and Effect of Exercise

骨骼肌保存能力随衰老的减少和运动的影响

• 批准号: 09680101
• 负责人: ISHIHARA Akihiko
• 金额: $ 2.18万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680101/
• 关键词: Aging; Exercise Training; Preserved Capacity; Skeletal Muscle

Program-1A voluntary running wheel in which a known load can be added electronically was developed. A voluntary exercise with an additional load resulted in fiber hypertrophy which was proportional to the average running distance. In addition, a recruitment of all motor unit type was induced during loaded-running exercise since fiber hypertrophy was observed in all fiber types in the muscle.Program-2The age-related changes in the number and SDH activity of muscle fibers and motoneurons of the tibialis anterior and soleus were studied using 1 0-, 60-, and 120-week-old rats. The number of fast-twitch muscle fibers was decreased at 60 weeks of age, while the number of slow-twitch muscle fibers and alpha motoneurons was decreased at 1 20 weeks of age. In addition, SDH activity of large alpha motoneurons was decreased at 1 20 weeks of age. Therefore, the degenerative process of muscle fibers differs between the fast- and slow-twitch muscles.Program-3Forty-week-old rats exercised voluntarily in running wheels with increasing loads for 20 weeks. There were fewer FOG fibers in the soleus muscle, and fewer FG fibers in the tibialis anterior muscle at 60 weeks than at 20 weeks of age. The cross-sectional area of FOG and FG fibers in the tibialis anterior muscle was lower at 60 weeks than at 20 weeks of age. Exercise prevented atrophy of FOG fibers in the tibialis anterior muscle. These findings suggest that exercise can prevent the atrophy of FOG fibers by restoring their decreased metabolic capacity, and by inhibiting the degeneration of neuromuscular junctions.

程序-1一个自愿运行轮，其中一个已知的负载可以添加电子开发。一个自愿的额外的负荷运动导致纤维肥大，这是成比例的平均跑步距离。此外，招聘的所有运动单位类型的负荷运行exercise诱导，因为纤维肥大观察到在所有的纤维类型在muscle.Program-2 The与年龄相关的变化，肌纤维和运动神经元的胫骨前肌和比目鱼肌的数量和SDH活性进行了研究，使用10-，60-，和120周龄的大鼠。快缩肌纤维的数量在60周龄时减少，而慢缩肌纤维和α运动神经元的数量在1 - 20周龄时减少。此外，大α运动神经元的SDH活性下降，在1 - 20周龄。因此，肌肉纤维的退化过程不同的快，慢twitch muscle.Program-3 40周龄的大鼠自愿行使在运行轮与增加负荷20周。60周龄时比目鱼肌中FOG纤维和胫骨前肌中FG纤维的数量比20周龄时少。胫骨前肌中FOG和FG纤维的横截面积在60周龄时低于20周龄时。运动可防止胫前肌FOG纤维萎缩。这些发现表明，运动可以通过恢复其降低的代谢能力和抑制神经肌肉接头的变性来防止FOG纤维的萎缩。