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Physio-pharmacological effects of intravenous anesthetic agent ; Propofol on respiratory depression

静脉麻醉剂的生理药理作用；

基本信息

批准号：
09671547
负责人：
MASUDA Akira
金额：
$ 0.7万
依托单位：
Toyama Medical & Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671547/
关键词：
Respiration Respiratory depression Human volunteer Uric acid Propofol Thiamylal Sevoflurane Swallowing reflex Respiratory control

项目摘要

In the first year, we compared the effect of propofol with that of sevoflurane anesthesia on uric acid (UA) excretion in ASA physical status I and II patients with normal renal function. A propofol group (n=11) received propofol-nitrous oxide-fentanyl after induction of anesthesia by propofol while a sevoflurane group (n= 12) received sevoflurane-nitrous oxide-fentanyl after induction of anesthesia by thiamylal. UA, creatinine (Cr), and urea nitrogen concentrations in serum and urine were measured before induction of anesthesia, 1, 2, and 3h after induction, and at 1 postoperative day. N-acety1-beta-D-glucosaminidase, beta_2-microglobulin concentrations and pH in urine were also examined. Plasma clearance of UA (CUA) and Cr (CCr) were calculated. The hourly concentration and excretion of urine UA were significantly higher than those of the sevoflurane. Significant correlations were noted between the hourly urine volume and UA concentration. The CUA of the propofol group was significantly higher than that of the sevoflurane group. There were no significant differences in other renal variables between the two groups. This study demonstrated that the UA excretion increased during propofol anesthesia, while it remained stable during sevoflurane anesthesia.In the second year, we investigated the effects of propofol and thiamylal on swallowing reflex in 26 adult volunteers. They were sedated with either propofol (Group P : n=16) or thiamylal (Group T : n=10). Swallowing was induced by bolus injections of distilled water (0.25, 0.5, 0.75 and 1.0 mL) into the pharynx via an epidural catheter. The responses to injections of water were analyzed in terms of the number of swallows elicited and the latency of response. The latency was prolonged and the number of swallows were decreased in Group F, but not in Group T.These results suggest that propofol depresses swallowing reflex greater than that of thiamylal.

在第一年，我们比较了异丙酚和七氟醚麻醉对肾功能正常的阿萨I级和II级患者尿酸（UA）排泄的影响。丙泊酚组（n=11）在丙泊酚诱导后给予丙泊酚-氧化亚氮-芬太尼，七氟醚组（n= 12）在硫糖铝诱导后给予七氟醚-氧化亚氮-芬太尼。分别于麻醉诱导前、诱导后1、2、3 h及术后第1天测定血尿酸（UA）、肌酐（Cr）、尿素氮（BUN）浓度。同时检测尿N-乙酰-β-D-氨基葡萄糖苷酶、β_2-微球蛋白浓度和pH值。计算血浆尿酸清除率（CUA）和肌酐清除率（CCr）。尿UA的小时浓度和排泄量均显著高于七氟醚。每小时尿量与UA浓度之间存在显着相关性。丙泊酚组的CUA显著高于七氟醚组。两组间其他肾脏变量无显著差异。本研究证明，在异丙酚麻醉期间，尿酸排泄增加，而在七氟醚麻醉期间，尿酸排泄保持稳定。在第二年，我们研究了异丙酚和硫戊巴比妥对26名成年志愿者吞咽反射的影响。分别用异丙酚（P组，n=16）和硫戊巴比妥（T组，n=10）镇静。通过硬膜外导管向咽部推注蒸馏水（0.25、0.5、0.75和1.0 mL）诱导吞咽。根据引发的吞咽次数和响应潜伏期分析对水注射的响应。F组吞咽反射潜伏期延长，吞咽次数减少，而T组无明显变化。