Gastrointestinal absorption and protein energy metabolism in infants with chronic lung disease

患有慢性肺疾病（CLD）的婴儿中的不足和增长失败仍然是儿科医生的主要临床问题之一，但原因是未知的。最近的一份报告显示，隐性是CLD病理学中的主要贡献因素。我们测量了能量代谢和脂质体在非常低的出生体重婴儿中的活性，以及脂蛋白和胰蛋白酶的混合二烯果汁（VLBWI），但没有CLD。测试13个VLBWI的能量代谢差异（6个有CLD，7个没有CLD），代谢气体监测仪（MGM/Jr.）它曾被用于生产氧化物消费品和碳二氧化物。Oxygen consumption （9.9±1.3 versus 8.5±1.1 ml/kg/min ： p<0.05）， and energy expenditure （71.6±10.3 versus 61.1±7.9 kcal/kg/Day ： p<0.05） were higher in infants with CLD。总能量摄入量（ 80.2±11.9对98.2±7.9千卡/千克/天： p<0.01）低于CLD的婴儿。脂蛋白和胰蛋白酶的活动是在20 VLBWI中进行的前寄生二次试验中测量的，在8周后自然期。这两种酶的活动都明显地增加了后自然年龄。这20个infants分布在两个组中，相当于氧气补充的周期和氧气支持的周期。The pancreatic enzyme activity of the infants who needed longer O-D22-D2 supplementation and ventilatory support were lower than the others。从这些结果中，我们总结了需要在VLBW基础上使用的VLBW基础设施，其中需要一个长期的卫生保健支持。

Undernutrition and growth failure in infants with chronic lung disease (CLD) remains one of the major clinical problems for pediatricians, but the cause is unknown. Recent reports showed that undernutrition is a major contributing factor in the pathogenesis of CLD. We measured the energy metabolism and the activities of lipase and trypsin in aspirated duodenal juice of very low birth weight infants (VLBWI) with and without CLD. To examine the difference in energy metabolism of 13 VLBWI (6 cases with CLD, 7cases without CLD), a metabolic gas monitor (MGM/jr.) was used to obtain oxygen consumption and carbon dioxide production. Oxygen consumption (9.9±1.3 versus 8.5±1.1 ml/kg/min : p<0.05), and energy expenditure (71.6±10.3 versus 61.1±7.9 kcal/kg/day : p<0.05) were higher in infants with CLD. Total energy intake ( 80.2±11.9 versus 98.2±7.9 kcal/kg/day : p<0.01) was lower in infants with CLD. The activities of lipase and trypsin were measured in preprandially aspirated duodenal juice of 20 VLBWI during 8 weeks of postnatal period. The activities of both enzymes significantly increased with postnatal age. These 20 infants were allocated into two groups according to oxygen supplemented period and ventilatory supported period. The pancreatic enzyme activity of the infants who needed longer OィイD22ィエD2 supplementation and ventilatory support were lower than the others. From these results, we concluded that careful and individual nutritional management was needed in the VLBW infants with CLD who require long term ventilatory supports.