PCR analysis herpes simplex virus brainstem and myelitis

对日本九州和冲绳1993-1995年调查发现的39例中枢神经系统单纯疱疹病毒(HSV)感染患者的资料进行了分析。同时进行巢式聚合酶链式反应(PCR)分析和酶免疫吸附试验(EIA)。颞叶边缘脑炎为播散性脑脊髓炎(ADEM)3例，脑膜炎2例，弥漫性脑炎2例，脑干型1例，其他5例。本组病例中有2例复发，11例延长住院6个月以上。本研究明确了HSV-CNS感染包括HSV相关性ADEM、脑干脑炎、脊髓炎和脑膜炎等多种类型。HSV-1和HSV-2分化的PCREIA分析包括少数HSV-2感染患者。另发现2例非疱疹急性边缘脑炎。这些数据与我们之前在1990-1992年进行的相同地区的研究进行了比较。

We analyzed data from 39 patients with herpes simplex virus (HSV) infections of central nervous system (CNS) found in a 1993-1995 survey in Kyushu and Okinawa, Japan. Additionally nested polymerase chain reaction (PCR) analysis and enzyme immunosorbent assay (EIA) were conducted. Temporal lobe-limbic encephalitis was disseminated encephalomyelitis (ADEM) (3), meningitis (2), diffuse encephalitis (2), brainstem type (1) and other (5). There were also recurrent type (2 patients) and prolonged cases (11) hospitalized over 6 months in our study.Since the induction of PCR , this study clarified that HSV CNS infections consisted of wider forms such as HSV related ADEM, brainstem encephalitis, myelitis and meningitis. PCR EIA analysis of HSV 1 and 2 differentiation included a few patients with HSV 2 infections. Also, 2 patients with non-herpetic acute limbic encephalitis were found. These data are compared with our previous study performed same regions in 1990-1992.