PCR analysis herpes simplex virus brainstem and myelitis

我们分析了1993-1995年在日本九州和冲绳调查发现的39例中枢神经系统单纯疱疹病毒（HSV）感染患者的资料。此外，巢式聚合酶链反应（PCR）分析和酶免疫吸附试验（EIA）进行。颞叶边缘系统脑炎为播散性脑脊髓炎3例，脑膜炎2例，弥漫性脑炎2例，脑干型1例，其他5例。本研究还发现了复发型（2例）和迁延型（11例）患者，自PCR技术问世以来，HSV CNS感染的形式更为广泛，包括HSV相关的ADEM、脑干脑炎、脑炎和脑膜炎。PCR EIA分析HSV 1和2的分化包括少数HSV 2感染的患者。同时发现2例非疱疹性急性边缘叶脑炎，并与1990 ~ 1992年在同一地区的研究结果进行了比较。

We analyzed data from 39 patients with herpes simplex virus (HSV) infections of central nervous system (CNS) found in a 1993-1995 survey in Kyushu and Okinawa, Japan. Additionally nested polymerase chain reaction (PCR) analysis and enzyme immunosorbent assay (EIA) were conducted. Temporal lobe-limbic encephalitis was disseminated encephalomyelitis (ADEM) (3), meningitis (2), diffuse encephalitis (2), brainstem type (1) and other (5). There were also recurrent type (2 patients) and prolonged cases (11) hospitalized over 6 months in our study.Since the induction of PCR , this study clarified that HSV CNS infections consisted of wider forms such as HSV related ADEM, brainstem encephalitis, myelitis and meningitis. PCR EIA analysis of HSV 1 and 2 differentiation included a few patients with HSV 2 infections. Also, 2 patients with non-herpetic acute limbic encephalitis were found. These data are compared with our previous study performed same regions in 1990-1992.