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Immobilization of a Water-Soluble Host Molecule by Polyion Complexation with a Polymer

通过聚离子与聚合物络合固定水溶性主体分子

基本信息

批准号：
09650942
负责人：
TSUGE Akihiko
金额：
$ 2.18万
依托单位：
Kyushu Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650942/
关键词：
Calixarene Host-Guest chemistry Polyion complex Synthetic bilayer membrane ホストーゲスト化学

项目摘要

Complexation of macrocyclic compounds with guest molecules in water has always attracted a major interest since it can mimic the molecular recognition which is a basic process in biological systems. Although modified cyclodextrins have been extensively investigated in terms of inclusion, recognition, and catalysis in aqueous media, versatility of their structure is limited. On the contrary water-soluble calixarenes cyclophanes have a great advantage of molecular design. If these water-soluble host molecules could be taken out from the aqueous solution without altering their properties by immobilization, it would facilitate their application as practical materials exhibiting enzyme-like functions. 1n order to accomplish immobilized calixarenes as novel functional materials, the following requirement must be satisfied ; they are not dissolved in water because they are supposed to give full function at the water interface. As the second the ionic character should be remained after immobilization because electrostatic interaction as well as hydrophobic interaction plays a decisive role as a driving force for recognition of the guest molecules. Formation of polyion complex between a cationic calix[6]arene ammonium chloride which has a long alkyl chain and an anionic chondroitin sulfate results in the precipitate in the aqueous solution. After dissolving the complex in a organic solvent, evaporation of this solution gives rise to the water-insoluble transparent film. The film is strong enough for handling and shows a binding of Methyl Orange molecule, indicating that it retains a fundamental function of the parent host molecule. Immobilization of an anionic sulfonated calix[6]arene can also be achieved by formation of polyion complex with a cationic poly (diallyldimethylammonium chloride). The film prepared from this complex exhibits the ability to incorporate Phenol Blue molecule, which suggests that the binding site still remains in the polyion complex film.

大环化合物与水中客体分子的络合一直引起人们的广泛兴趣，因为它可以模拟分子识别，这是生物系统中的基本过程。尽管改性环糊精在水介质中的包合、识别和催化方面已得到广泛研究，但其结构的通用性有限。相反，水溶性杯芳烃环芳烃在分子设计方面具有很大的优势。如果这些水溶性主体分子可以从水溶液中取出而不通过固定改变其性质，则将有助于它们作为具有酶样功能的实用材料的应用。 1为了实现固定化杯芳烃作为新型功能材料，必须满足以下要求；它们不溶于水，因为它们应该在水界面处发挥全部功能。其次，固定化后应保留离子特征，因为静电相互作用和疏水相互作用作为客体分子识别的驱动力起着决定性作用。具有长烷基链的阳离子杯[6]芳烃氯化铵与阴离子硫酸软骨素之间形成聚离子络合物导致水溶液中沉淀。将络合物溶解在有机溶剂中后，蒸发该溶液产生不溶于水的透明薄膜。该薄膜的强度足以处理，并显示出甲基橙分子的结合，表明它保留了母体主体分子的基本功能。阴离子磺化杯[6]芳烃的固定也可以通过与阳离子聚(二烯丙基二甲基氯化铵)形成聚离子络合物来实现。由该复合物制备的薄膜表现出结合酚蓝分子的能力，这表明结合位点仍然保留在聚离子复合物薄膜中。