High Performance Analysis of Environmental-Interest Analytes by Non-Aqueous Capillary Electrophoresis

研究了非水溶液毛细管电泳（CE）对环境污染物和环境污染物的分析。研究了非水CE手性分离、环糊精（CD）衍生物的组成对水CE手性分离的影响、在线CE -质谱（MS）对除草剂对映体的立体选择分离和检测、新型手性表面活性剂胶束电动色谱（MEKC）手性分离以及在线浓度的MEKC对二恶英及其相关化合物的高灵敏度分析。二甲基甲酰胺、二甲基亚砜（DMSO）、丙酮和四氢呋喃（THF）是非水CE.2的有效溶剂。用- cd /DMSO或- cd /甲酰胺溶液进行非水CE手性分离除草剂对映体和丹酰dl氨基酸。采用OD-R聚合物/丙酮或OD-R聚合物/四氢呋喃溶液，采用非水CE法实现了药物组分对映体的手性分离。（OD-R聚合物为手性聚合物。）研究了商品二甲基- β - cds的组成对CD修饰毛细管区带电泳手性识别的影响。利用β - cd衍生物，成功地实现了CE-MS对苯氧酸类除草剂对映体的手性分离和检测。一些药物成分对映体和dl -氨基酸衍生物用新型手性表面活性剂进行了MEKC光学拆分。采用在线富集技术对CD修饰的MEKC进行了二恶英相关化合物的高灵敏度分析。采用手性固定相毛细管电色谱法，实现了部分药物成分的手性分离。

Analysis of environmental-interest analytes or environmental pollutants by capillary electro phoresis (CE) using non-aqueous solutions was investigated. Chiral separations by non-aqueous CE, effects of compositions of cyclodextrin (CD) derivatives in chiral separations by aqueous CE, stereoselective separation and detection of herbicides enantiomers by on-line CE - mass spectrometry (MS), chiral separations by micellar electrokinetic chromatography (MEKC) using novel chiral surfactants, and high sensitive analysis of dioxins and related compounds by MEKC with on-line concentration were studied.1. Dimethylformamide, dimethylsulfoxide (DMSO), acetone, and tetrahydrofuran (THF) were found to be effective solvents for non-aqueous CE.2. Chiral separations of herbicide enantiomers and dansyl-DL-amino acids were achieved by non-aqueous CE using a beta-CD/DMSO or beta-CD/formamide solution.3. Chiral separations of drug component enantiomers were achieved by non-aqueous CE using an OD-R polymer/acetone or OD-R polymer/THF solution. (OD-R polymer is a chiral polymer.)4. Effects of compositions of commercial dimethyl-beta-CDs on chiral recognitions in CD modified capillary zone electrophoresis were investigated.5. Chiral separation and detection of phenoxy acid herbicide enantiomers by CE-MS using beta-CD derivatives was successfully achieved.6. Some drug component enantiomers and DL-amino acid derivatives were optically resolved by MEKC using novel chiral surfactants.7. High sensitive analysis of dioxin related compounds were carried out by CD modified MEKC using an on-line concentration technique.8. By using capillary electrochromatography with chiral stationary phases, chiral separations of some drug components were achieved.