Novel heart failure pharmacotherapy that targets nuclear signaling pathway in cardiac myocytes

针对心肌细胞核信号通路的新型心力衰竭药物疗法

• 批准号: 15K09108
• 负责人: HASEGAWA Koji
• 金额: $ 3.08万
• 依托单位: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09108/
• 关键词: 循環器・高血圧; シグナル伝達; 薬学; トランスレーショナルリサーチ

项目成果

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.

• DOI: 10.2147/copd.s104490
• 发表时间: 2016
• 期刊: International journal of chronic obstructive pulmonary disease
• 影响因子: 2.8
• 作者: Funamoto M;Sunagawa Y;Katanasaka Y;Miyazaki Y;Imaizumi A;Kakeya H;Yamakage H;Satoh-Asahara N;Komiyama M;Wada H;Hasegawa K;Morimoto T
• 通讯作者: Morimoto T

Protein Arginine Methyltransferase 5/Methylosome Protein 50 Complex Inhibits p300 Histone Acetyltransferase Activity and Hypertrophic Gene transcription in Cultured Cardiomyocytes

蛋白精氨酸甲基转移酶 5/甲基小体蛋白 50 复合物抑制培养心肌细胞中 p300 组蛋白乙酰转移酶活性和肥大基因转录

• 发表时间: 2015
• 作者: Yusuke Miyazaki;Yasufumi Katanasaka;Yoichi Sunagawa;Hiromichi Wada;Koji Hasegawa and Tatsuya Morimoto
• 通讯作者: Koji Hasegawa and Tatsuya Morimoto

Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach

使用蛋白质组学方法对心脏肥大反应转录因子 GATA4 复合物进行功能分析

• DOI: 10.1248/yakushi.15-00226-2
• 发表时间: 2016
• 期刊: YAKUGAKU ZASSHI
• 影响因子: 0.3
• 作者: Sunagawa Y;Katanasaka Y;Wada H;Hasegawa K;Morimoto T.
• 通讯作者: Morimoto T.

Histone Acetylation Domain by p300 are Changed During the Transition From Cardiac Hypertrophy to Heart Failure Circulation. 2017;136:A18911. (Abstract 18911)

p300 的组蛋白乙酰化结构域在从心脏肥大到心力衰竭循环的转变过程中发生变化。

• 发表时间: 2017
• 作者: Masafumi Funamoto;Yoichi Sunagawa;Yasufumi Katanasaka;Yusuke Miyazaki;Hiromichi Wada;Koji Hasegawa and Tatsuya Morimoto
• 通讯作者: Koji Hasegawa and Tatsuya Morimoto